Triprolidine and pseudoephedrine

Triprolidine and pseudoephedrine (Actifed) PO 2.5 mg q6-8h max 10 mg/d Pregnancy category B Protein bound Unknown Half-hfe 3 hours... 

The HPLC chromatogram of an extract from a linctus containing pseudoephedrine, dextromethorphan, triprolidine and methylparaben. ODS column 25 cm x 4.6 mm, mobile phase acetonitrile/0.05 M phosphate buffer pH 6.8 (35 65) 1 ml/min. UV monitoring at 260 nm. 

Triprolidine hydrochloride and pseudoephedrine hydrochloride Second derivative spectrophotometiic method was proposed for simultaneous determination of pseudoephedrine hydrochloride (PSE) and triprolidine hydrochloride (TRI). The second derivative amplitudes of PSE and TRI were measured at 271 and 321 nm, respectively. The calibration curves were linear in the range of 200 to 1,000 pg mL-i for PSE and 10 to 50 pg mL-ifor TRI. 33... 

Actifed is a medicinal preparation in which the effective components are the two drugs pseudoephedrine hydrochloride and triprolidine hydrochloride. The absorption spectrum of Actifed tablets dissolved in 0.1M hydrochloric acid is similar to that shown in Fig. 17.14(a) which is clearly of no value for quantitative determinations. A second derivative spectrum however is similar in character to that shown in Fig. 17.14(6) in which peak C corresponds to the pseudoephedrine hydrochloride and D to the triprolidine hydrochloride and from which it is possible to make quantitative measurements. Experience showed that it is advisable to use different response times for the two peaks with the instrument used a response setting of 3 was found to give the best results for pseudoephedrine hydrochloride, whilst a setting of 4 was best for the triprolidine hydrochloride. 

Triprolidine is an antihistamine. Phenylpropranolamine, pseudoephedrine, phenylephrine and oxymetazoline are nasal decongestants. Nasal decongestants administered systemically are often available in combination with an antihistamine. 

A) UV spectrum of an extract elixir containing pseudoephedrine. dextromethorphan and triprolidine. (B) Second derivative spectrum of the extract. Note the absorbance maximum of dextromethorphan disappears. 

Pseudoephedrine hydrochloride 30 mg, triprolidine hydrochloride 1.25 mg, dextromethorphan bromide 10 mg and preservatives. 

X 10 ml of chloroform. The chloroform layers are combined and evaporated to dryness using a rotary evaporator. The residue is dissolved in ca 10 ml of methanol and transferred to a 100 ml volumetric flask and then diluted to volume with mobile phase. The areas of the peaks obtained from the linctus extract are compared with a solution containing pseudoephedrine.HCl, dextromethorphan.HBr and triprolidine.HCl (structures shown in Fig. 11.14) at the same concentrations as would be expected in the linctus extract. 

The SFC analysis of mercaptopurine, trimethoprim, triprolidine, pseudoephedrine, permethrin, zidovudine, and trifluridine was reported by Mulcahey and Taylor [9]. The mobile phase was carbon dioxide containing methanol and the packed column was a cyanopropyl (250 x 4.6 mm ID). Figures 7.11 and 7.12 show separations of the compounds of interest. In order to elute trimethoprim from the column without severe tailing, tetra-... 

Following oral administration of 2.5 mg of triprolidine hydrochloride and 60 mg of pseudoephedrine hydrochloride four times a day to 17 subjects for 5 days, peak plasma-triprolidine concentrations of 0,004 to 0.044 pg/ ml (mean 0.013) were reported about 1.6 hours after a dose (J. G. Perkins etal., Curr. ther. Res., 1980,28, 650-668),... 

Akhtar, M.J. Khan, S. Hafiz, M. High-performance Liquid chromatographic assay for the determination of paracetamol, pseudoephedrine hydrochloride and triprolidine hydrochloride. J.Pharm. BiomedAnal., 1994, 12, 379—382 [simultaneous pseudoephedrine, triprolidine formulations]... 

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