2.3.6- Trimethyl-4- phenyl acetate

The reaction of potassium 3-amino-4-oxo-3,4-dihydroquinazoline-2-thiolate 62 with a-bromophenylacetic acid 63 resulted in the formation of (3-amino-4-oxo-3,4-dihydroquinazolin-2-ylsulfanyl)-phenyl-acetic acid methyl ester 64 which on alkali treatment and subsequent acidification resulted in the synthesis of 2-phenyl- 1-thia-4,4a,9-triaza-anthracene-3,10-dione 65 <1999JCR(S)86>. Similarly, the reaction of potassium 3-amino-5,6-dimethyl-4-oxo-3,4,4a,7a-tetrahydrothieno[2,3- pyrimidine-2-thiolate 66 with a-bromo-ester 67 resulted in the formation of 2-(3-amino-5,6-dimethyl-4-oxo-3,4,4a,7a-tetrahydrothieno[2,3- / pyrimidin-2-ylsulfanyl)-propionic acid ethyl ester 68. Subsequent treatment with alkali followed by acidification resulted in the formation of 2,3,7-trimethyl-3a,9a-dihydro-l,8-dithia-4a,5,9-triazacyclopenta[ ]naphthalene-4,6-dione 69 <2000JHC1161>... 

C-Benzyl-C,N-dimethyl- E14b, 1422 (aus CI/NO-Acetal) (Z)-N-Benzyl-C-ethyl- El4b, 1446 (Keton + R-NH-OH) N-(2,4,6-Trimethyl-phenyl)- E14b, 1485 (Amin + R-NO)... 

Cleavage of 3,4-epoxy-3-methyl-1-butene in its reaction with 2,3,5-trimethyl -4-acetoxyphenol at ambient temperature in the presence of a catalytic amount of tetrakis(triphenylphosphine)palladium(0) occurred at the more highly-substituted side to give 2,3,6-trimethyl-4-(1-hydroxymethyl-1-methylallyloxy)-phenyl acetate without chroman formation (ref. 179). 

Citronellal acetone 2,6-Dibromo-3-methyl-4-nitroanisole 2-Ethylhexanal ethyleneglycol acetal Geraniol Isononanal diethyl acetal Isononanal dimethyl acetal Isononanal methylanthranilate Lilial methylanthranilate 4-Methyl-4-phenyl-2-pentyl isobutyrate Phenylacetaldehyde dicitronellyl acetal Thiogeraniol Tricyclodecane methylol acetate Trimethyl cyclohexyl acetate fragrance, synthetic beverages Benzaldehyde... 

Thus,as shown in Equation 8.17,the oxidation of the diarylenol,2-(2, 4, 6 -trimethyl-phenyl)-2-phenyl-l-ethenol with lead tetracetate in warm ethanoic acid (acetic acid, CH3CO2H) yields the corresponding acetoxyaldehyde. 

Phenyl isocyanate, with ethyl hydrazine-carboxylate to give 4-phenyl-l-car-bethoxysemicarbazide,51,122 Phenylmercuric acetate, with methallyl alcohol to yield 2-methyl-3-phenyl-propionaldehyde, 51, 17 1-PHENYL-1,3-PENTADIYNE, 50, 97 1-PHENYL-1,4-PENTADIYNE. 50, 97 a-Phenylpentanal, from 2-benzyl-4,4,6-trimethyl-5,6-dihydro-l,3(4H)-... 

In the Mukaiyama aldol additions of trimethyl-(l-phenyl-propenyloxy)-silane to give benzaldehyde and cinnamaldehyde catalyzed by 7 mol% supported scandium catalyst, a 1 1 mixture of diastereomers was obtained. Again, the dendritic catalyst could be recycled easily without any loss in performance. The scandium cross-linked dendritic material appeared to be an efficient catalyst for the Diels-Alder reaction between methyl vinyl ketone and cyclopentadiene. The Diels-Alder adduct was formed in dichloromethane at 0°C in 79% yield with an endo/exo ratio of 85 15. The material was also used as a Friedel-Crafts acylation catalyst (contain-ing7mol% scandium) for the formation of / -methoxyacetophenone (in a 73% yield) from anisole, acetic acid anhydride, and lithium perchlorate at 50°C in nitromethane. 

ACETONE TRIMETHYLS ILVL ENOL ETHER SILANE, (ISOPROPE NYLOXY )TR IMETHYL SILANE, TRIMETHYL[(1-METHYLETHENYL)0XY]- (1833-53-0), 65, 1 Acetonitrile, purification, 66, 101 Acetophenone Ethanone, 1-phenyl- (98-86-2), 65, 6, 119 Acetophenone silyl enol ether Silane, trimethyl[(1-phenylvinyl)oxy] Silane, tririethyl[(l-phenylethenyl )oxy]- (13735-81-4), 65, 12 4-ACET OXYAZET ID IN-2-ONE 2-AZET IDINONE, 4-HYDROXY-ACETATE (ESTER) 2-AZET ID1N0NE, 4-(ACETYL0XY)- (2 8562 - 53-0), 65, 135 Acetylene Ethyne (74-86-2), 65, 61... 

Alkyl phenyl ketonesAlkylation of the anion of 1 followed by oxidation and rearrangement gives a mixed acetal, which is hydrolyzed by acid to a ketone (cf. Phenylthiomethyl(trimethyl)silane, this volume). 

Radical cyclization of allylsiloxy derivatives 148 to l-oxa-2-silacycloheptanes 149 was achieved by treatment of 2-(allyldimethylsiloxy)-l,l-dibromoalkanes with Bun3SnH in the presence of a catalytic amount of triethylborane in benzene (Equation 27). An interesting stereochemical outcome was observed in the cyclization of 1-allyldimethylsi-loxy-2,2-dibromo-l-phenylpropane (R1 = H, Rz = Ph) which gave a stereoisomeric mixture of 2,2,6-trimethyl-7-phenyl-l-oxa-2-silacycloheptane (cisftrans = 87/13). These seven-membered cyclic silyl ethers and acetals were stable and could be isolated by silica-gel column chromatography <1997BCJ2255>. 

The reaction of ate complexes (24), formed from trialkylboranes and trimethyl-silylpropargyl phenyl ether, with a mixture of acetic acid and hexamethylphosphoric triamide (HMPT) gives trimethylsilylacetylenes (25) selectively (Eq. 54) whereas the corresponding trimethylsilylallenes (26) are selectively prepared by the reaction with sodium methoxide instead of acetic acid and HMPT (Eq. 54) In the latter, when primary alkylboranes are used, the corresponding allene derivatives are obtain in high purity, but secondary alkylboranes give reverse ratios of the isomer distribution. 

Oxo-4-phenyl-1,3,3-trimethyl-E16b, 274 (Imin 4- Keten-di acetal)... 

Oxazolidin 4-Hydroxy-2-oxo-3-phenyl-4,5,5-trimethyl- E14a/2. 453 (intra O/N-Acetal-Bild.)... 

Pyrimidin 6-Hydroxy-l-phenyl-2-thiono-4,4,6-trimethyl-hexa-hydro- El4a/2, 456 (intra O/N —Acetal-Bild.)... 

CARBENES, GENERATION Benzyltrieth-ylammonium chloride. Dehydro-N,N, N -tricyclohexylguanidinohexacarbonyldi-iron(O). Ethylene oxide. Ethyl trichloro-acetate. Phenyl(l-bromo-l-chloro-2,2,2-trifluoroethyI)mercury. Phenyl(trihalo-methyl)mercury. Trimethyl-silyldiazo-methane. 

The procedure involves reaction in acetic anhydride, or in another solvent, followed by the addition of acetic anhydride to decompose the intermediate complex. The procedure has been extensively examined in relation to the 5-methyl- and 4,5-dimethyl-substituted compounds derived from ethenyl methyl and methyl isopropenyl ketones and with mesityl oxide which gives the 3,3,5-trimethyl-substituted compounds. Amongest the phosphorus reactants, the trichloride itself and methyl- " , ethyl- " " and phenyl- phosphonous dichlorides have been employed, as have ethyl and phenyP dichlorophosphites, ROPCI2. The use of 2-thienylphosphonous dichloride to give 137 is recorded as is that of the unsaturated ketone 138 to give 139. A more novel conversion is that of 140 into 141 in 25% yield with a similar conversion (15%) being observed for cholest-4-en-3-one. ... 

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