Trilaurin/Tripalmitin

The evolution of the fat crystal network of tricqnin and tristearin mixture as a fimction of time was followed by NMR and polarized microscopy in order to establish a correlation between crystal size and spin-lattice relaxation time. The T distributions were also measured for two solid mixtures of tricaprin/tristearin and trilaurin/tripalmitin in order to determine erystal size distribution in a solid mixture. 

Two different systems of triacylglycerols, i.e. tricaprin and tristearin on the one hand and trilaurin and tripalmitin on the other, were studied in the solid state at three different concentrations 25 75, 50 50, 75 25 (w/w). For the tricaprin/tristearin system, the mixtures were melted at 80°C and then cooled to -50°C for 10 min. The temperature was finally increased to 10°C for 30 min. For the trilaurin/tripalmitin system, the mixtures were melted at 80 C and then cooled to -20°C for 10 min. The sample was first reheated to 0°C for 20 min and then to 20°C for 30 min before NMR measurements. 

COCONUT OIL. Contains trimyristin, trilaurin, tripalmitin, tristearin, other glycerides. Coconut oil has been stored in aluminum alloy tanks. See also Ref (7) p, 93. 

Trilaurin (Dynasan 112) Trimyristin (Dynasan 114) Tripalmitin (Dynasan 116) Hard fat (Witepsol H42) Hard fat (Witepsol W35)... 

TG Standards (13) Obtain tricaproin (tri-C6), triheptanoin (tri-C7), tricaprylin (tri-C8), trinonanoin (tri-C9), tricaprin (tri-CIO), triundecanoin (tri-Cll), trilaurin (tri-C12), tritridec-anoin (tri-C13), trimyristin (tri-C14), tripentadecanoin (tri-CIS), tripalmitin (tri-C16), triheptadecanoin (tri-C17), and tristearin (tri-C18) with a minimum purity of 99% (available from Nu Check Prep., Inc., Elysian, MN). 

Quite recently, van Langevelde et al. examined the crystal structures of the p form of tripalmitin (PPP) in comparison with the results of tricaprin (CCC) (38, 39), trilaurin (LLL) (36), and predicted the p form structure of trimyristin (MMM) (38). As shown in Table 1, the unit cell parameters, double-chain length structure, and T// subcell structure of the three TAGs are almost the same, except... 

TABLE 1. Unit Cell Parameters of p Form of Tricaprin (CCC), Trilaurin (LLL), and Tripalmitin (PPP) (V Unit Cell Volume, D Density). 

Various lipids including triglycerides (e.g., trilaurin, trimyristin, tripalmitin and tristearin) and fatty acids were evaluated as carrier materials in sustained-release insulin implants. The drug/wax powder blend was compressed into a disc and implanted subcutaneously into Wistar rats. Monoglycerides tested eroded too fast and were not suitable. The triglycerides only sustained-the insulin release briefly. The best sustained-release properties were obtained with palmitic and stearic acids as the carrier materials. 

The quantity of bound flavouring substance also depends on the chain length of the fatty acids in the triglyceride, and on the presence of saturated or unsaturated fatty acids in it. Triglycerides with long chain fatty acids bind less ethanol and ethyl acetate than those with short chain fatty acids [6]. Triolein - a triglyceride that only contains the unsaturated oleic acid - binds more flavour than tripalmitin and trilaurin (both of which contain only saturated fatty acids) [6]. 

Sucrose tribehenate Syrup Trihydroxystearin Trilaurin Trimyristin Tripalmitin... 

Hydroxyoctacosanyl hydroxystearate PEG-4 polyglyceryl-2 stearate Polyglyceryl-3 beeswax Tallow alcohol Trilaurin Trimyristin Tripalmitin consistency agent, emulsions Gum ghatti... 

Sucrose myristate Sucrose polystearate Sucrose stearate Sucrose tetrastearate triacetate Sucrose tribehenate Trihydroxystearin Trilaurin Trimyristin Tripalmitin... 

Styrene/butadiene polymer Sulfated butyl oleate Tallamide DEA Tall oil Tall oil acid Tallow Tallow acid Tallowamide DEA Tetrasodium EDTA Titanium dioxide Trilaurin Trimyristin Triolein Tripalmitin Trisodium EDTA... 

Stearamide DIBA-stearate Stearamine oxide Stearone Stearyl stearate 2-Tetradecyloctadecanol Trilaurin Trimyristin Tripalmitin Triundecanoin Tromethamine magnesium aluminum silicate... 

Figure 8.58 Relation between the solubilities in 100% ethanol of trilaurin, trimyristin, tripalmitin and tristearin (Arnold et al, 1963).

This experiment thus suggested that trilaurin and tripalmitin tend to form co-crystals, which behave similarly to the triacylglycerol in excess, and that polymorphic modification of trilaurin is slowed down by the presence of tripalmitin. 

Name Tricaprylin Tricaprin Trilaurin Trimyristin Tripalmitin Tristearin Triarachidin Tribehenin... 

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