Trifluoperazine

Chemical Name 10-[3-(4-methylpiperazin-1-yl)propyl] 2-trifluoromethylphenothiazine Common Name Triftazin triphthasine Structural Formula [Pg.1538]

Trade Name Manufacturer Country Year Introduced [Pg.1538]

A mixture of 17.2 grams of 2-trifluoromethylphenothiazine, 3.1 grams of sodamide and 14 grams of 1-(3 -chloropropyl)-4-methylpiperazine in 200 ml of xylene is heated at reflux for 2 hours. The salts are extracted Into 150 ml of water. The xylene layer is then extracted with several portions of dilute hydrochloric acid. The acid extracts are combined and neutralized with ammonium hydroxide solution. The product, 10-[3 -(4 -methyl-1 piperazinyO-propyl]-2-trifluoromethylphenothiazine, is taken into benzene and purified by vacuum distillation, BP 202° to 210°C at 0.6 mm. [Pg.1539]

Ullyot, G.E. U.S. Patent 2,921,069 January 12, 1960 assigned to Smith Kline French Laboratories [Pg.1539]

A combination of amphotericin B, miconazole (16), and rifampin (17) was used to successfully cure one patient. In addition, tetracycline (7) and minocycline (18) have been recommended although their clinical efficacy have not been estabUshed. No proven therapeutic agents exist for treating A.catbamoeba infections, however, the phenothiazines, trifluoperazine [117-89-5] and chlorpromazine [50-53-3], show promise in vitro. [Pg.262]

Trifluoperazine dihydrochloride (10-[3- 4-methyl-l-piperazinyl propyl]-2-trifluoro-methyl-phenothiazine 2HCI) [440-17-5] M 480.4, m 240-243 , 242-243 , pK, 3.9, pKj 8.1. [Pg.572]

Dyazide - Hydrochlorothiazide Dyazide - Triamterene Dycill Dicloxacillin sodium Dyclone Dyclonine HCI Dyflex - Dyphylline Dygratyl Dihydrotachysterol Dylate - Papaverine monophosadenine Dymadon - Acetaminophen Dymelor - Acetohexamide Dymenol Dimenhydrinate Dymoperazine - Trifluoperazine Dynalase - Chlorpropamide... [Pg.1695]

The multidrug resistance (mdr) reversing effect of the new phenothiazine complexes were tested on mouse T cell lymphoma cell lines. Trifluoperazine (TFP) was much more effective at the same concentration than verapamil. The efficacy of some metal coordination complexes [TFP-Cu(ll) and TFP-V(IV)] exceeded the action of TFP alone. Chlorpromazine (CPZ) or CPZ-Pt(ll) complex had the same or less effect than verapamil or promethazine (Pz) used as a control. [Pg.429]

Tranquis (Sumitomo) Trifluoperazine (Yoshitomi) USA Stelazine (SmithKline Beecham)... [Pg.2108]

C (H 7C1N2 104-16-5) see Butaperazine Perazine Prochlorperazine Thiethylperazine Thioproperazine Trifluoperazine... [Pg.2414]

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