Trifluoperazine interaction with

Clinically important, potentially hazardous interactions with abacavir, amiodarone, bretylium, chlorpromazine, ciprofloxacin, disopyramide, enoxacin, fluphenazine, gatifloxacin, lomefloxacin, mesoridazine, moxifloxacin, norfloxacin, ofloxacin, phenothiazines, procainamide, prochlorperazine, promethazine, quinidine, quinolones, sotalol, sparfloxacin, thioridazine, trifluoperazine... 

Clinically important, potentially hazardous interactions with alcohol, anticholinergics, barbiturates, benzodiazepines, butabarbital, chloral hydrate, chlordiazepoxide, chlorpromazine, clonazepam, clorazepate, diazepam, ethchlorvynol, fluphenazine, flurazepam, hypnotics, lorazepam, MAO inhibitors, mephobarbital, mesoridazine, midazolam, narcotics, oxazepam, pentobarbital, phenobarbital, phenothiazines, phenylbutazone, primidone, prochlorperazine, promethazine, quazepam, secobarbital, sedatives, temazepam, thioridazine, tranquilizers, trifluoperazine, zolpidem... 

Clinically important, potentially hazardous interactions with atazanavir, chlorpromazine, cimetidine, co-trimoxazole, degarelix, fluphenazine, ketoconazole, medroxyprogesterone, megestrol, mesoridazine, phenothiazines, prochlorperazine, progestins, promethazine, ranolazine, thioridazine, trifluoperazine, trimethoprim, verapamil, zuclopenthixol... 

Clinically important, potentially hazardous interactions with amiodarone, amisulpride, amitriptyline, amoxapine, arsenic, bepridil, bretylium, calcium, chlorpromazine, clomipramine, desipramine, disopyramide, doxepin, erythromycin, fluphenazine, imipramine, iron salts, magnesium, mesoridazine, nortriptyline, pentamidine, perphenazine, phenothiazines, pimozide, procainamide, prochlorperazine, promazine, promethazine, protriptyline, quinidine, sotalol, sucralfate, thioridazine, tricyclic antidepressants, trifluoperazine, trimipramine, zinc salts... 

Simple addition of the hypotensive effects of both drugs seems to be the explanation for the increased hypotension and orthostasis. The suggested explanation for the hypertensive interaction with methyldopa and trifluoperazine is that the phenothiazine blocked the reuptake of the false transmitter (alpha-methyl noradrenaline) that is produced during when methyldopa is given. ... 

Trifluoperazine, 10-[3-(4-methyl-l-piperazinyl)pro-pyl]-2-trifluoromethylthiophenazine, a drug that binds to Ca -calmodulin and inhibits its interaction with other proteins, reversibly inhibited growth and phagocytosis of polyvinyltoluene latex beads (2.97 pm diameter) in a macrophagelike cell line, J774.16 (Horwitz et al. 1981). 

The dynamics and orientation of a lipophilic drug, trifluoperazine, within model membranes determined by solid-state Helix orientations in membrane-associated Bcl-X-L, an anti-apoptotic protein the function of which is linked to its reversible interaction with mitochondrial outer membranes, determined by... 

W Caetano, M Tabak. Interaction of chlorpromazine and trifluoperazine with anionic sodium dodecyl sulfate (SDS) micelles electronic absorption and fluorescence studies. J Coll Inter Sci 225 69—81, 2000. 

We also have used 19F NMR and ICD spectra to study interactions of trifluoperazine with calmodulin under various conditions where no aggregation of trifluoperazine occurs. Antipsychotic drugs such as trifluoperazine (TFP) are strongly bound to calmodulin (CaM) in the presence of Ca2+ and behave as potent CaM antagonists I60161>. 

Detailed interaction studies have been performed with the neuroleptic drugs cis-and trans-flupentixol. These stereoisomers, like trifluoperazine, act as modifiers of multidrug resistance in tumor cell lines, in which it has been observed that the trans isomer is about three times as potent as the cis form. Surprisingly, it was found that, in the case of these two stereoisomers, the slope of the curve 1/T2 vs. lecithin concentration is different. The steeper slope for tram-flu perilixol suggests that it interacts about twice as strongly with lecithin as does cis-flupentixol (Figure 3.38) [133],... 

Tab. 5.27 Correlation coefficients between drug-membrane interaction parameters and biological data of the seven modifiers studied, (c/s- and trans-flupentixol, chlorpromazine, trifluoperazine, triflupromazine, imipramine, and quinacrine). Chlorpromazine was omitted from regression corresponding to the MCF-7/DOX cell line. Quinacrine data were not available for the P388/DOX cell line. (Reprinted from Tab. 2 of ref. 11 7, with permission from Bertelsmann-Springer)...

Our conductrimetric work [207] with three hydrochloride psychotropes—chlorpromazine, trifluoperazine, and methotrimeprazine—also showed that these formed charge-transfer complexes with acetylcholine, 6-hydroxydopamine, and noradrenaline which were not highly associated. Two different types of interaction occurred, one in which a single product was formed, and a second which involved two almost simultaneous reactions. In the former case the product was stable to ultraviolet light, while in the latter case the more slowly formed product was strongly UV sensitive. The reactions in solution were first order. 

INDIRECT ANTIPSYCHOTICS 1. Case reports of paralytic ileus with trifluoperazine and methylphenidate 2. Case report of acute dystonias with haloperidol and dexamfetamine 3.1 efficacy of chlorpromazine when dexamfetamine was added 1. Additive anticholinergic effect 2. Uncertain possibly due to t dopamine release 3. Uncertain 1. Watch for signs of altered bowel habit 2. Warn patients of this rare interaction 3. Avoid co-administration... 

Phospholipid monolayers provide useful models for studying dmg-lipid interactions as we can see from the following recent example which explores the interaction of the pheno-thiazine drugs trifluoperazine (TFP) and chlor-promazine (CPZ) with the anionic glycero-phospholipid dipalmitoylphosphatidylglycerol (DPPG). The surface pressure isotherms of... 

Detailed interaction studies have a been performed with the neuroleptic drugs cis- and trara-flupentixol. These stereoisomers also act like trifluoperazine as modifiers of multidrug resistance in tumor cell lines where it has been observed that the rra i-isomer is... 

The concurrent use of MAOIs and phenothiazines is usually safe and effective. However, rarely, cases of possible neuroleptic malignant syndrome or hyperpyrexia have been reported with MAOIs and chlorpromazine, levomepromazine or trifluoperazine. Some of these cases were fatal Chiorpromazine has been successfully used for treatment of the serotonin syndrome occurring with MAOIs and other drugs. Moclobemide has been used with various phenothiazines without problem, but one case of fatal overdose is attributed to an interaction between moclobemide and perazine. 

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