Extrapyramidal symptom trifluoperazine

The clinical manifestations of overdosage of trifluoperazine include CNS depression characterized by deep, unarousable sleep and possible coma, hypotension or hypertension, extrapyramidal symptoms, dystonia, abnormal involuntary muscle movements, agitation, seizures, arrhythmias, ECG changes, hypothermia or hyperthermia, and autonomic nervous system dysfunction. 

A New Zealand study describes a patient who developed extrapyramidal symptoms when given trifluoperazine and fluoxetine. ... 

Clomacran (SKF 14336, 10) in further studies was found to be as effective as trifluoperazine with somewhat fewer side effects2 and almost identical to chlorpromazine but with a relatively higher incidence of extrapyramidal symptoms ... 

---