Triclofos sodium

Trade Name Manufactu rer Country Year Introduced 

Chemical Name 2,2,2-trichloroethanol dihydrogen phosphate monosodium salt Common Name Trichloroethyl phosphate monosodium salt Structural Formula  

Chemical Abstracts Registry No. 7246-20-6 306-52-5 (Base) Trade Name Manufacturer Country 

The ether filtrate and washings were evaporated at room temperature under reduced pressure to give a clear liquid residue (801 grams). This residue was distilled under high vacuum to give trichloroethyl phosphorodichloridate (556 grams, 62.4% of theory), boiling point 75°C/0.8 mm. 

The phosphorodichloridate was hydrolyzed by adding to a stirred solution of sodium carbonate (253 grams) in water (2.9 liters). After 1 hour the solution was cooled and acidified with a solution of concentrated sulfuric acid (30 ml) in water (150 ml) and then extracted with a mixture of tetrahydrofuran and chloroform (2.3/1 3 x 1 liter). The tetrahydro-furan/chloroform liquors were bulked and evaporated to dryness to give a light brown oil. This was dissolved in water (1 liter) and titrated with 2N sodium hydroxide solution to a pH of 4.05 (volume required 930 ml). The aqueous solution was clarified by filtration through kieselguhr and then evaporated under reduced pressure to a syrup (737 grams). 

Trade Name Manufacturer Country Year Introduced 

---

Triclofos Sodium Dissolve 25 mg in 10 ml of DW, add 4 ml of 1 M H2S04, 1 ml of a 10% w/v soln. of ammonium molybdate and 2 ml of a methylaminophenol-sulphite soln. and allow to stand for 15 minutes. Add sufficient DW to produce 25 ml, allow to stand for a further 15 minutes and measure the absorbance of a 4 cm layer of the resulting soln. at 730 nm. Calculate the content of Phosphate from a calibration curve prepared by treating suitable vols. of a 0.00143% w/v soln. of KH2P04 in the same manner. NMT 1.0% calculated as po43-. 

Triclilormelhia ide. 605-610. 606l. f)0Xl Trichloroeihanol. meiabutism of. 112 Trichomoniasis, 260 Triclofos sodium. 4%... 

R—O--PO3H phosphate ester hydrocortisone sodium phosphate, triclofos sodium... 

---