4.4.6- trichlorophenol

Data Base, Jan. 2001 l-hydroxy-2,4,6-trichlorobenzene FLUKA CHEMIE 

9 in H2O soluble in alkaline solutions, readily soluble in organic solvents 

LD50 intraperitoneal Moderately to severely irritant to skin, mucosa and eyes. 

Highly toxic for fish (LCo 0.5mg/l) and activated sludge organisms. 

Gonalez et al. (1996) found that Alcaligenes eutrophus is capable for the degradation of 2,4,6-trichlorophenol. 

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C12H4CI4O2. A by-product in the preparation of 2,4,5-trichlorophenol from 1,2,4,5-tetrachlorobenzene, sodium hydroxide and ethylene glycol. Causes chloracne in humans. 

In the course of making 24 5 trichlorophenol it al most always becomes contaminated with small... 

The starting material for this process 24 5 trichlorophenol is made by treating 1 2 4 5 tetra chlorobenzene with aqueous base Nucleophilic... 

The synthesis of chlorarul [118-75-2] (20) has been improved. The old processes starting from phenol or 2,4,6-trichlorophenol have been replaced by new ones involving hydroquinone chlorination. These processes allow the preparation of chlorarul of higher purity, avoiding traces of pentachlorophenol. Different types of chlorination conditions have been disclosed. The reaction can be performed according to the following stoichiometry, operating with chlorine in aqueous acetic acid (86,87), biphasic medium (88), or in the presence of surfactants (89). 

Several antimicrobials have been banned or severely restricted by the EPA based on documented or suspected toxicity or environmental problems. Others have been discontinued in the face of testing costs required by the EPA reregistration program mandated by the Pederal Insecticide, Pungicide, and Rodenticide Act (PIPRA) of 1988 (10). Some of the significant products that have become obsolete are 2,4,5-trichlorophenol/P3 -5 3 -47, sodium... 

Peroxyoxalate chemiluminescence is the most efficient nonenzymatic chemiluminescent reaction known. Quantum efficiencies as high as 22—27% have been reported for oxalate esters prepared from 2,4,6-trichlorophenol, 2,4-dinitrophenol, and 3-trif1uoromethy1-4-nitropheno1 (6,76,77) with the duorescers mbrene [517-51-1] (78,79) or 5,12-bis(phenylethynyl)naphthacene [18826-29-4] (79). For most reactions, however, a quantum efficiency of 4% or less is more common with many in the range of lO " to 10 ein/mol (80). The inefficiency in the chemiexcitation process undoubtedly arises from the transfer of energy of the activated peroxyoxalate to the duorescer. The inefficiency in the CIEEL sequence derives from multiple side reactions available to the reactive intermediates in competition with the excited state producing back-electron transfer process. 

Oxidation of saligenin with chromic acid or silver oxide yields saUcyladehyde as the first product. Further oxidation results in the formation of sahcyhc acid, which is also obtained when saligenin is heated with sodium hydroxide at 200—240°C. Chlorination of an aqueous solution of the alcohol gives 2,4,6-trichlorophenol, and bromination in an alkaline medium yields 2,4,6-tribromophenol and tribromosaligenin. When saligenin is heated with one mole of resorcinol in the presence of anhydrous zinc chloride, 3-hydroxyxanthene forms. 

With the discontinuation of some herbicides, eg, 2,4,5-trichlorophenol [39399-44-5] based on the higher chlorinated benzenes, and DDT, based on monochlorobenzene, both for ecological reasons, the production of chlorinated benzenes has been reduced to just three with large-volume appHcations of (mono)chlorobenzene, o-dichlorobenzene, and -dichlorobenzene. Monochlorobenzene remains a large-volume product, considerably larger than the other chlorobenzenes, in spite of the reduction demanded by the discontinuation of DDT. 

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