Tri-O-methyl-P-cyclodextrin

Otagiri, M., Imai, T., Uekama, K. Enhanced oral bioavailability of anti-inflammatory drug flurbiprofen in rabbits by tri-O-methyl-p-cyclodextrin complexation. J. Pharmacobio-Dynam. 1982, 5, 1027-1029. 

I Tsukushi, O Yamamuro, H Suga. Heat capacities and glass transitions of ground amorphous solid and liquid-quenched glass of tri-O-methyl-P-cyclodextrin. J Non-Crystall Solids 175 187, 1994. 

This method was proposed by P. Husek (ref. 5) and involves the analysis of the lactic acid in the form of dioxolanone using GC on a chiral stationary phase comprising a derivative of the p-cyclodextrine heptakis (2,3,6 tri O methyl) p-cyclodextrine. The derivatization reaction is as follows ... 

Nakai, Y., Yamamoto, K., Terada, K., et al. (1983) Interaction of tri-0-methyl-P-cyclodextrin with drugs, enhanced bioavailability of keto-profen in rats when administered with tri-O-methyl-P-cyclodextrin. Chem. Pharm. Bull 31 3745-3747. 

Several physical studies have been carried out on cyclodextrin derivatives. Thus the X-ray structure of per-(6-bromo-6-deoxy-2,3-di-0-methyl)P-cyclodextrin has been examined by single crystal X-ray diffraction analysis. The conformation deviates significantly from C symmetry. Likewise the X-ray structure of heptakis-2,3,6-tri-C>-methyl-P-cyclodextrin shows that one of the seven rings is inverted. Conformational analysis of an extensive set of per-O-substituted p-cyclodextrins reveals that several show conformational isomerism. The relevance of this to the use of cyclodextrins in molecular device design is examined. Related work undertook n.m.r. and molecular modeling studies on a-cyclodextrin in vriiich one of the units is in the 3,6-anhydro from. The work included the examination of two model disaccharide imits. ... 

X.X. Dai, R.J. Synergistic effect of heptakis(2,3,6-tri-0-pentyl)-P-cyclodextrin and o-methyl-j7-phenylene-bis-(p-heptoxy benzoate) mixed stationary phase in capillary gas chromatography. J. Chromatogr. Sci. 1999, 37, 395-399. 

Acenaphthene n-Amyl alcohol Arachidic acid Arachidyl alcohol Benzidine dihydrochloride 2-Butyl octanoic acid Butyloctanol Calcium sulfate Cetylarachidol Cocamine Cocopropylenediamine Cyclodextrin p-Cyclodextrin 1,10-Decanediol 2-Decyl tetradecanoic acid Dihydroxyethyl cocamine oxide Dodecylhexadecanol 2-Hexyl decanoic acid Hydroxypropyl-o-cyclodextrin Hydroxypropyl-P-cyclodextrin Hydroxypropyl-y-cyclodextrin 12-Hydroxystearyl alcohol Isobutyl oleate Kelp Lead phthalate, basic Methoxyethanol 2-Methoxy-5-nitroaniline Methoxy tripropylene glycol acrylate Methylene chloride 2-Octyl dodecanoic acid Oleamine PEG-25 castor oil PEG-30 castor oil PEG-36 castor oil PEG-40 castor oil PEG-200 castor oil PEG-5 hydrogenated castor oil PEG-25 hydrogenated castor oil Polyamide Polysorbate 85 Pyridine Quartz Sodium isopropyl naphthalene sulfonate Soybean (Glycine soja) meal Sucrose Sulfur Tallow amine N-Tallow-1,3-diaminopropane dioleate p-Toluene sulfonic acid Tri methyl amine Tungstic acid Undecylenic acid Vinyl compounds and polymers plastics additive... 

---