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Flurbiprofen, anti-inflammatory drug

Electropherograms of a urine sample (8 ml) spiked with non-steroidal anti-inflammatory drugs (10 p-g/ml each) after direct CE analysis (b) and at-line SPE-CE (c). Peak identification is as follows I, ibuprofen N, naproxen K, ketoprofen P, flurbiprofen. Reprinted from Journal of Chromatography, 6 719, J. R. Veraait et al., At-line solid-phase exti action for capillary electrophoresis application to negatively charged solutes, pp. 199-208, copyright 1998, with permission from Elsevier Science. [Pg.287]

Orthoformates have been used in the lipase-catalyzed esterification aimed at the kinetic resolution of racemic acids such as flurbiprofen, a nonsteroidal anti-inflammatory drug (Figure 6.18). Orthoformates trap the water as it is formed through hydrolysis, and therefore prevent the reverse reaction, and, at the same time, provide the alcohol for the esteriflcation [65]. [Pg.141]

Castell, J.V, Larrauri, A. and Gomez-Lechon, M.J. (1988). A study of the relative hepatotoxi-city in vitro of the non-steroidal anti-inflammatory drugs ibuprofen, flurbiprofen and butibufen. Xenobiotica 18 737-745. [Pg.678]

Lelievre and Gareil (31) studied chiral separations of nonsteroidal anti-inflammatory drugs (carprofen, flurbiprofen, indoprofen, ketoprofen, naproxen, propafenone, and suprofen) and determined the acidity and inclusion complex formation constants of these chiral compounds with different neutral CDs (/3-CD, HP-/3-CD, DM-/3-CD, TM-/3-CD, and HP-y-CD). In... [Pg.200]

Synthesis of the anti-inflammatory drug flurbiprofen by an environmentally efficient Suzuki coupling that uses water as the solvent and palladium on carbon as a reusable catalyst. [Pg.794]

Figure 4 Nonsteroidal anti-inflammatory drugs, acetaminophen, and caffeine separated by CEC on a 75-mm-i.d. column packed with 5-mm ODS Nucleosil particles immobilized within a polymer matrix. Mobile phase 70% acetonitrile/30% acetate, 10 mM (pH 3.0). UV detection at 254 and 220 nm 20 kV applied, effective length 17 cm, total length 26 cm. Analytes (1) unknown impurity (2) acetaminophen (3) caffeine (4) aspirin (5) naproxen (6) flurbiprofen (7) ibuprofen. (Reprinted from Ref. 22, with permission.)... Figure 4 Nonsteroidal anti-inflammatory drugs, acetaminophen, and caffeine separated by CEC on a 75-mm-i.d. column packed with 5-mm ODS Nucleosil particles immobilized within a polymer matrix. Mobile phase 70% acetonitrile/30% acetate, 10 mM (pH 3.0). UV detection at 254 and 220 nm 20 kV applied, effective length 17 cm, total length 26 cm. Analytes (1) unknown impurity (2) acetaminophen (3) caffeine (4) aspirin (5) naproxen (6) flurbiprofen (7) ibuprofen. (Reprinted from Ref. 22, with permission.)...
Flurbiprofen is a cyclooxygenase (COX)-inhibiting non-steroidal anti-inflammatory drug (NSAID). The COX-inhibiting activity resides primarily in the (S)-enantiomer whereas the (R)-enantiomer has scarce COX activity. (R)-Flurbiprofen has been found to inhibit tumor growth in various animal models. In vitro experiments have shown that this effect is based on the induction of a cell cycle block and apoptosis [21]. [Pg.86]

Topical nonsteroidal anti-inflammatory drugs (NSAIDs), such as bromfenac, diclofenac, ketorolac, and nepafenac, have been advocated, but there is evidence that commercially available preparations do not appear effective in treating episcleritis. Topical flurbiprofen and ketorolac were foimd to be no more effective than placebo in treating episcleritis therefore, treatment modalities other than topical NSAIDs should be used. [Pg.578]

Gaspaiini L, Ongini E, Wilcock D, Morgan D (2005) Activity of flurbiprofen and chemically related anti-inflammatory drugs in models of Alzheimer s disease. Brain Res Rev 48 400- 08. [Pg.104]

Sore throat treatments contain demulcents, antibacterials and local anaesthetics, and many products contain combinations of these. One sore throat lozenge contains flurbiprofen, a non-steroidal anti-inflammatory drug... [Pg.134]

Otagiri, M., Imai, T., Uekama, K. Enhanced oral bioavailability of anti-inflammatory drug flurbiprofen in rabbits by tri-O-methyl-p-cyclodextrin complexation. J. Pharmacobio-Dynam. 1982, 5, 1027-1029. [Pg.837]

Castell, J.V., Gomez-Lechon, M.J., Miranda, M.A., and Morea, I.M., 1992, Phototoxicity of non-steroidal anti-inflammatory drugs in vitro testing of the photoproducts of buti-bufen and flurbiprofen, J. Photochem. Photobiol. B-Biol. 13, 71-81. [Pg.102]

An improvement of medical devices based on bacterial polymers by the encapsulation of different drugs, opens up the wide prospects in applications for these new devices with pharmacological activity in medicine. PHB polymer was used as a drug delivery matrix for sustaining the release of various drugs such as dipyridamole [DP], indomethacin and antibiotics (rifampicin, metronidazole, ciprofloxacin, levofloxacin), anti-inflammatory drugs (flurbiprofen, dexamethasone, prednisolone), and antitumor drugs (paclitaxel) [132]. [Pg.310]

The hydrolysis of prodrugs of the chiral p-blocker propranolol and the nonsteroidal anti-inflammatory drug flurbiprofen (Fig. 13) by the hydrolases in the liver and small intestine microsomesis shown in Fig. 14 for different species [44,45]. Different propranolol prodrugs containing fatty acids of various chain lengths were hydrolyzed to different extents in both the liver and the small intestine of all the studied species except for the small intestine of the dog. Additionally, the hydrolysis was stereoselective in favor of the R-enantiomer for all the species and both tissues except for the Hver microsomes of rats, which showed opposite stereoselectivity (Fig. 14). However, the differences in hydrolysis between the R- and S-isomers were larger in liver microsomes, compared with those in the microsomes of the small intestine, in all animal species examined (Fig. 14). [Pg.133]

The 2-arylpropionic acid class (2-APA) of nonsteroidal anti-inflammatory drugs (NSAlDs) (Table 1) is characterized by each member having an asymmetric carbon a to the carboxylic acid moiety. The R-enantiomer of this chiral center of some 2-APAs may undergo an in vivo inversion to the S-enantiomer. This inversion process varies substantially between the different members of this class and also varies between species of animal studied. The members of this class that are currently in clinical use include ibuprofen, ketoprofen, tiaprofenic acid, fenoprofen, and flurbiprofen. The majority are marketed as racemates. Naproxen and its sodium salt are internationally marketed as the pure S(-l-)-enantiomer, while ibuprofen and ketoprofen are now marketed in several European countries as the stereochemically pure S(-l-)-enantiomer. [Pg.361]

Knihinicki, R.D. Williams, K.M. Day, R.O. Chiral inversion of 2-aryl-propionic acid non-steroidal anti-inflammatory drugs—1. In vitro studies of ibuprofen and flurbiprofen. Biochem. Pharmacol. 1989, 38, 4389-4395. [Pg.390]


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See also in sourсe #XX -- [ Pg.349 ]




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