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Intermediates and transition states

Another means of resolution depends on the difference in rates of reaction of two enantiomers with a chiral reagent. The transition-state energies for reaction of each enantiomer with one enantiomer of a chiral reagent will be different. This is because the transition states and intermediates (f -substrate... f -reactant) and (5-substrate... R-reactant) are diastereomeric. Kinetic resolution is the term used to describe the separation of enantiomers based on different reaction rates with an enantiomerically pure reagent. [Pg.89]

The negatively charged ring in the transition state and intermediate complex presumably exerts little or no inductive electron attraction on a substituent. So, as one might expect, the transition-state effect of an azine methoxy group can differ from its (conjugated)... [Pg.224]

Draw an energy diagram for a two-step reaction with Kecj > 1. Label the overall AG°, transition states, and intermediate. Js AG° positive or negative ... [Pg.168]

The big difference between the extent of asymmetric induction on the addition to a prostereogenic carbonyl group of simple carbanions a to a chiral sulfoxide on the one hand and enolates of sulfinyl esters on the other, can be attributed to the capacity of the ester function to chelate magnesium in the transition states and intermediates. The results already described for the addition of chiral thioacetal monosulfoxide to aldehydes (see Section 1.3.6.5.) underscore the importance of other functions, e.g., sulfide, for the extent of asymmetric induction. [Pg.659]

A careful distinction must be drawn between transition states and intermediates. As noted in Chapter 4, an intermediate occupies a potential energy minimum along the reaction coordinate. Additional activation, whether by an intramolecular process (distortion, rearrangement, dissociation) or by a bimolecular reaction with another component, is needed to enable the intermediate to react further it may then return to the starting materials or advance to product. One can divert an intermediate from its normal course by the addition of another reagent. This substance, referred to as a trap or scavenger, can be added prior to the start of the reaction or (if the lifetime allows) once the first-formed intermediate has built up. Such experiments are the trapping experiments referred to in Chapters 4 and 5. [Pg.126]

It is possible to take advantage of the differing characteristics of the periphery and the interior to promote chemical reactions. For example, a dendrimer having a non-polar aliphatic periphery with highly polar inner branches can be used to catalyse unimolecular elimination reactions in tertiary alkyl halides in a non-polar aliphatic solvent. This works because the alkyl halide has some polarity, so become relatively concentrated within the polar branches of the dendrimer. This polar medium favours the formation of polar transition states and intermediates, and allows some free alkene to be formed. This, being nonpolar, is expelled from the polar region, and moves out of the dendrimer and into the non-polar solvent. This is a highly efficient process, and the elimination reaction can be driven to completion with only 0.01 % by mass of a dendrimer in the reaction mixture in the presence of an auxiliary base such as potassium carbonate. [Pg.144]

J. M. Thomas, C. R. Catlow and G. Sankar, Determining the structure of active sites, transition states and intermediates in heterogeneously catalysed reactions, Chem. Commun., 2002, 2921. [Pg.178]

In the end, what is unique about computational methods is their ability to describe transition states and intermediates. This is why the calculation of reaction mechanisms has achieved such a prominent position in quantum biochemistry. We will therefore spend a considerable amount of time to describe when improved active-site geometries can be expected to give important beneficial effects on reaction energies. In addition, we will try to describe how the non-bonded interactions between active site and surrounding protein affect relative energies. [Pg.32]

In many cases the most interesting results of a computational study are the relative energies of transition states and intermediates because they determine the reaction mechanism. In this section we will try to outline when improved active-site geometries can be expected to have important effects on relative energies. [Pg.48]

For oxetane formation from formaldehyde and ethylene, we should consider the following four transition states and intermediates for the reaction<181) ... [Pg.104]

Kinetic data and bromine bridging in transition states and intermediates 225 Product data and bromine bridging from stereo- and regio-chemistry 234... [Pg.207]

What is retained nowadays of the initial mechanism (Scheme 1) is the occurrence of a cationic intermediate. But bromine bridging is not general, and its magnitude depends mainly on the double bond substituents (Ruasse, 1990). For example, when these are strongly electron-donating, i.e. able to stabilize a positive charge better than bromine, / -bromocarbocations are the bromination intermediates. The flexibility of transition state and intermediate stabilization puts bromination between hydration via carbocations and sulfenylation via onium ions. [Pg.209]

KINETIC DATA AND BROMINE BRIDGING IN TRANSITION STATES AND INTERMEDIATES... [Pg.225]

Co2(CO)q system, reveals that the reactions proceed through mononuclear transition states and intermediates, many of which have established precedents. The major pathway requires neither radical intermediates nor free formaldehyde. The observed rate laws, product distributions, kinetic isotope effects, solvent effects, and thermochemical parameters are accounted for by the proposed mechanistic scheme. Significant support of the proposed scheme at every crucial step is provided by a new type of semi-empirical molecular-orbital calculation which is parameterized via known bond-dissociation energies. The results may serve as a starting point for more detailed calculations. Generalization to other transition-metal catalyzed systems is not yet possible. [Pg.39]

From the data provided by the systematic experimental study at standardized conditions the free energy of activation (AG exp.) was calculated from the experimental rate constant and compared to calculated AG values. Two different basis sets have been employed in the DFT calculations the split valence double- (DZ) basis set 6-31G(d) with a triple- (TZ) [44, 45] valence basis set for manganese (we will refer to this combination as basis set I (BS1)) and the triple- basis set 6-311+G(d,p), which will be denoted basis set n (BS2). The BSl-results for transition states and intermediates are shown in Table 5, a comparison of the free activation energies is shown in Figure 8 [46],... [Pg.262]

Another way of visualising the potential energy of a molecular system is in terms of the potential-energy changes that occur during a chemical reaction. This is represented by means of a reaction profile where the potential energy values of the reactants, products, transition states and intermediates are plotted against the reaction coordinate (the lowest... [Pg.122]

The stability of substrates, products and (often delicate) catalysts, transition states and intermediates, in the solvent. [Pg.2]

Reaction mechanisms divide the transformations between organic molecules into classes that can be understood by well-defined concepts. Thus, for example, the SnI or Sn2 nucleophilic substitutions are examples of organic reaction mechanisms. Each mechanism is characterized by transition states and intermediates that are passed over while the reaction proceeds. It defines the kinetic, stereochemical, and product features of the reaction. Reaction mechanisms are thus extremely important to optimize the respective conversion for conditions, selectivity, or yields of desired products. [Pg.3]


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See also in sourсe #XX -- [ Pg.305 ]




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And transition states

Intermediate state

Intermediates transition state, 5, 6, 7

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