Transcription biological

Burley, S.K., Boeder, R.G. Biochemistry and structural biology of transcription factor IID. Anna. Rev. Bioehem. 

Cellular screening systems can be developed with primary human cells cultured in biologically relevant contexts. The outputs of these systems are focused sets of biologically relevant parameters (gene transcription, protein... 

Gallinari P, Di Marco S, Pallaro M et al (2007) HDACS, histone deacetylation and gene transcription from molecular biology to cancer therapeutics. Cell Res 17 195-211... 

The possible combinations generated by these mechanisms could be sufficient to account for ligand-specific and cell-specific biological responses, notwithstanding the limited number of second messengers that are available for the transcription of the primary response genes (Herschman, 1989). It is apparent that much remains to be done to understand the complexity of the cytoskeleton and its interactions within cells and across cell membranes. 

Nakai, A., Morimoto, R.I. (1993). Characterization of a novel chicken heat shock transcription factor, heat shock factor 3, suggests a new regulatory pathway. Molecular Cellular Biology 13, 1983-1997. 

Yost, H.J., Petersen, R.B., Lindquist, S. (1990). Post-transcriptional regulation of heat shock protein synthesis in Drosophila In Stress Proteins in Biology and Medicine (Morimoto, R., Tissieres, A. Georgopoulos, C., eds.), pp. 379-409, CSH Laboratory Press, Cold Spring Harbor. 

Metzger, D., Ah, S., Bomert, J.M., and Chambon, P. (1995). Characterization of the amino-terminal transcriptional activation function of the human estrogen-receptor in animal and yeast-ceUs. Journal of Biological Chemistry 270, 9535-9542. 

This early biological result spurred a variety of biochemical studies of the interactions of various polyamides with the basal transcription machinery and TE-DNA complexes. Two studies have used promoter scanning to identify sites where polyamide binding inhibits transcription [64, 65]. The method uses a series of DNA constructs with designed polyamide binding sites at varying distances from... 

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