Molecular biology transcription

Gallinari P, Di Marco S, Pallaro M et al (2007) HDACS, histone deacetylation and gene transcription from molecular biology to cancer therapeutics. Cell Res 17 195-211... 

The chemical functioning of a cell is the main objective of Molecular Biology (MB). The isolation, identification, and purification of biomacromolecules could be seen as the first step, in fulfilling this objective. From the catalytic point of view, enzymes are the center of attention. However, the most important biomolecule in the cell is the DNA, in which the genetic code of each enzyme is enclosed, thus representing ultimate target for MB. The biochemical and molecular processes of replication, transcription, and translation become part of the objective. 

Molecular biology involves the study of the major macromolecules, DNA, RNA, and protein. The central dogma ofmolecular biology is illustrated in Fig. 2. The central dogma shows the relationship among the macromolecules in the processes of transcription and translation. Figure 2 also gives the relationship between immunoelectron microscopy and in situ hybridization. In situ hybridization allows one to localize a specific nucleic acid sequence. Immunoelectron microscopy is an essential component to the technique of in situ hybridization when applied at the EM level. 

Horn PJ, Peterson CL (2002) Molecular biology Chromatin higher order folding — Wrapping up transcription. Science 297 1824-1827... 

Transcription and Disease Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur P O, Bangalore 560064, India... 

Sterner DE, Berger SL (2000) Acetylation of histones and transcription-related factors. Microbioloby and Molecular Biology Reviews 64(2) 435 59... 

P. J. Horn, and C. L. Peterson, Molecular biology. Chromatin higher order folding—wrapping up transcription. Science 297, 1824—1827 (2002). 

Francis Crick enunciated the central dogma of molecular biology in 1958 DNA directs its own replication and its transcription to RNA that, in turn, directs its translation to protein. This statement is frequently oversimplified to DNA makes RNA makes protein. ... 

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