Tranquilizers mental effects

The most significant beneficial mental effects of the major and minor tranquilizers include ... 

From alcohol and methamphetamine to Prozac, Valium, lithium, and Zyprexa, psychoactive substances disguise their adverse mental effects for the user. A person grossly mentally impaired by stimulants, benzodiazepine tranquilizers, mood stabilizers, or neuroleptics is likely to have little idea about how dysfunctional he or she has become. When the individual does perceive a change in himself or herself, positive or negative, it is almost never attributed to the causative agent the drug. If the individual feels euphoric, it is attributed to good fortune and especially... 

Roizin, L., True, C., Knight, M. (1959). Structural effects of tranquilizers. Research Publications of the Association for Research in Nervous and Mental Disease, 37, 285—324. 

The odd fact is that much truly convincing evidence of nervous participation as contrasted with the mental has come from therapeutics. Think of the many drugs now available for the treatment of hypertension. Tranquilizers alone have not been effective, but where this aspect of their actions is combined with others as in reserpine, their partial effectiveness is unquestionable. Reserpine has both a central and peripheral action and seems chiefly involved in the release and storage of catecholamines and serotonin. 

Meanwhile, the era of tranquilizer therapy was dawning as successful isolation of crystalline reserpine facilitated the discovery of its unique effects on mental function, while more or less concurrently, astute clinical research revealed the then unique psychotherapeutic properties of chlorpromazine. 

Various drugs are invariably used in Parkinsonism for the following effects, first, to lower abnormal reflex rigidity and tremor, and restore normal motor activity e.g., natural atropine group of alkaloids, synthetic atropine substituted, antihistaminics secondly, to minimise mental depression-e.g., analeptics and thirdly, to allay restlessness, tension and anxiety-e.g., sedatives and tranquillizers. 

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