Toxicity precautions

TOXICITY, PRECAUTIONS, AND INTERACTIONS Abdominal discomfort, nausea, diarrhea, headache, dizziness, and drowsiness may occur shortly after taking praziquantel these direct effects are transient and dose-related. Indirect effects such as fever, pruritus, urticaria, rashes, arthralgia, and myalgia are noted occasionally and are related to parasite burden. In neurocysticer-cosis, inflammatory reactions to praziquantel may produce meningismus, seizures, mental changes, and CSF pleocytosis. These effects usually are delayed in onset, last 2-3 days, and respond to symptomatic therapy such as analgesics and anticonvulsants. 

Toxicology Nonhazardous low acute oral and skin penetration toxicity Precaution Incompat. virith cone, oxidizing or reducing agents since mixts. of these compds. with org. compds. could form a potentially explosive mixt. 

Properties Yel.-brown to translucent solid sol. in acetone, benzene, carbon disulfide, chloroform, hot petrol, ether, gasoline, oils, toluene, turpentine, CCI, sparingly sol. in alcohol pract. insol. in water dens. 0.983 m.p. 67-68 C acid no. 10-20 sapon. no. 50-65 ref. index 1.4555 Toxicoiogy No known toxicity Precaution Combustible... 

Toxicology Toxic Precaution Moderate fire risk... 

Toxicology LD50 (oral, rat) 4400 mg/kg, (skin, rabbit) 8100 mg/kg mildly toxic by ing. and skin contact vapor irritating to eyes, nose, and throat absorbed thru skin, but health effects unlikely mod. to severe eye irritant probable lachrymator low oral toxicity Precaution Combustible incompat. with oxidizing agents (increases fire/ explosion hazard), strong acids (may cause decomp, of ethers) Hazardous Decomp. Prods. Heated to decomp., emits acrid smoke and irritating fumes... 

Toxicology No known toxicity Precaution Combustible Hazardous Decomp. Prods. C02from combustion... 

Empirical CH2IO3S Na Properties Colorless cryst. sol. in water, methanol si. sol. in 95% ethanol pract. insol. in acetone, ether, benzene m.w. 244.99 Toxicology Toxic Precaution Sensitive to light Storage Store in tightly closed container under inert atmosphere store in a freezer Uses Radioopaque medium... 

Toxicology Toxic Precaution Combustible Uses Plasticizer solvent Manuf./Distrib. ChemService http //www. chemservice. com... 

Environmental Mod. aquatic toxicity Precaution Avoid strong oxidizers may release very flammable THF, CO, etc. 

Containers must be correcdy labelled with name and analysis of the product. Material safety data sheets giving aU important properties such as boiling and melting points, miscibihty with water and other solvents, inflammable nature, toxicity, precautions to be taken for safe handling, and how to collect and make a spillage harmless (absorb in ash/washing by copious amounts of water). 

Note XI.2 Warning—toxic. Precaution—See the product safety bulletins from the supplier of the chemicals used in preparing these columns or before Benzyl Cyanide-Silver Nitrate Column X1.1.3 Hexamethylphosphoramide (HMPA) column, and XI. 1.4 Dimethylsufolane (DMS) Benzyl Cyanide-Silver Nitrate Column. 

Toxicology LD50 (oral, rat) > 5000 mg/kg si. eye or skin irritant low oral toxicity Precaution Wear safety glasses where contact with the eyes is likely, use chemical goggles use impervious gloves and protective clothing keep away from heat, flames, and oxidizing materials... 

Features Compat. with anionic and nonionic surfactants Properties Pale yel. liq. sol. in ethanol, xylene, perchloroethylene, water insol. in min. oil, kerosene sp.gr. 1.13 (68 F) dens, 9,4 Ib/gal (68 F) acid no, 129 (pH 5,5), 248 (pH 9,5) pour pt, < 10 F flash pt, (PMCC) > 250 F pH 2-3 (1% aq,) surf, tens, 30,7 dynes/cm (0,05% aq,) 1% max, moisture Toxicology Nonhazardous acidic low acute oral and skin penetration toxicity Precaution Incompat, with cone, oxidizing or reducing agents as mixts, of these compds, with org, compds, form a potentially explosive mixt,... 

Toxicology May cause eye and skin irritation if ingested in large quanlilies, may cause Gl tract irritation generally not considered toxic Precaution Wear safety glasses, approved respirator, gloves, and lab coat... 

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