Toxic materials ingestion

Health and Safety Factors. Animal-feeding studies of DMPPO itself have shown it to be nontoxic on ingestion. The solvents, catalyst, and monomers that are used to prepare the polymers, however, should be handled with caution. Eor example, for the preparation of DMPPO, the amines used as part of the catalyst are flammable toxic on ingestion, absorption, and inhalation and are also severe skin and respiratory irritants (see Amines). Toluene, a solvent for DMPPO, is not a highly toxic material in inhalation testing the TLV (71) is set at 375 mg/m, and the lowest toxic concentration is reported to be 100—200 ppm (72). Toxicity of 2,6-dimethylphenol is typical of alkylphenols (qv), eg, for mice, the acute dermal toxicity is LD q, 4000 mg/kg, whereas the acute oral toxicity is LD q, 980 mg/kg (73). The Noryl blends of DMPPO and polystyrene have PDA approval for reuse food apphcations. 

Rosin has a low order of toxicity foUowing ingestion or skin contact. Rosin and its numerous derivatives have a number of permitted food packaging and other direct and indirect food contact uses throughout the world. Sanctioned uses appHcable in the United States are outlined in U.S. Food and Dmg Administration (U.S. FDA) Regulations (2). Material Safety Data Sheets (MSDSs) for specific rosins and thein derivatives should be consulted before thein use. 

Ingestion of toxic materials occurs only through accidental or careless procedures in the industrial environment and, while it caimot be ignored, it is seldom a significant factor in exposure. 

Health Hazards Information - Recommended Personal Protective Equipment Eye protection Symptoms Following Exposure Vapors from very hot material may irritate eyes and produce headache, drowsiness, and convulsions General Treatment for Exposure Remove fresh air. Wash affected skin areas with water. Flush eyes with water Toxicity by Inhalation (ThresholdLimit Value) 5 mg/m Short-Term Exposure limits Not pertinent Toxicity by Ingestion Grade 1 LDjq 5 to 15 g/kg Late Toxicity Birth defects in rats polyneuritis in humans Vapor (Gas) Irritant Characteristics Not pertinent liquid or Solid Irritant Characteristics No appreciable hazard. Practically harmless to the skin Odor Threshold Data not available. 

Health Hazards Information - Recommended Personal Protective Equipment Eye protection Symptoms Following Eiqzosure Dust irritates eyes in same way as any foreign material. Penetration of skin by fragments of metal is likely to produce local irritation, blisters, and ulcers which may become infected General Treatment for Exposure EYES flush with water to remove dust. SKIN treat as any puncture Toxicity by Inhalation (Threshold Limit Value) Data not available Short-Term Inhalation Limits Not pertinent Toxicity by Ingestion Oral LDLo (lowest lethal dose) = 230 mg/kg (dog) Late Toxicity Data not available Vtqtor (Gas) Irritant Characteristics Not pertinent Liquid or Solid Irritant Characteristics Data not available Odor Threshold Not pertinent. 

Health Hazards Information - Information included are recommended personal protective equipment for hazard materials handling specialist, typical symptoms following exposure to the chemical, general first aid treatment procedures, and various toxicological information including toxicity by ingestion, inhalation and short term exposures. Additional information included are the liquid or solid irritant characteristics and odor threshold data. 

Generally, the main pathways of exposure considered in tliis step are atmospheric surface and groundwater transport, ingestion of toxic materials that luu c passed tlu-ough the aquatic and tcncstrial food chain, and dermal absorption. Once an exposure assessment determines the quantity of a chemical with which human populations nniy come in contact, the information can be combined with toxicity data (from the hazard identification process) to estimate potential health risks." The primary purpose of an exposure assessment is to... 

Type 1. A heat-stable material, toxic on ingestion, which prevents completion of adult development in the pupal stage in certain susceptible Muscidae (6). 

Type 3. A heat-labile material, toxic on ingestion to several species of larch sawfly (31). 

Ingestion Toxicity Data are available for the acute (single-dose) ingestion/oral toxicity of many toxic materials (National Institute for Occupational Safety and Health, Registry of Toxic Effects of Chemical Substances, 1983 Lewis, Sax s Dangerous Properties of Industrial Materials, 9th ed., 1996). However, very few data are available for prolonged ingestion or periodic doses of toxic materials. It is likely that metabolic processes would operate to increase the total burden required for toxic effects for such chronic exposures, except for some materials (such as mercury and lead) which apparently can accumulate in the body. 

The 50 percent lethal doses of ingested toxic materials that could cause fatal injury (National Institute for Occupational Safety and Health, Registry of Toxic Effects of Chemical Substances, 1983). 

Conclusion Toxicity data are available for many thousands of solid, liquid, and gaseous chemicals and other materials. The data for inhalation toxicity provide guidance for concentration and duration limits, for protection of the public, chemical plant employees, and emergency response personnel. Similar data for ingestion and skin contact with toxic materials are not as readily available. Investigation into toxic effects is continuing, so that toxic materials can be handled safely. 

Dysprosium nitrate [Dy lNO l ] is a strong oxidizing agent and will ignite when in contact with organic material. Most dysprosium salts are toxic if ingested or inhaled. 

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