Total analysis system,

Micro Total Analysis Systems (pTAS) are chip-based micro-channel systems that serve for complete analytics. The word Total refers to the monolithic system character of the devices, integrating a multitude of miniature functional elements with minimal dead volumes. The main fields of application are related to biology, pharmacology, and analytical chemistry. Detailed applications of pTAS systems are given in Section 1.9.8. Recently, pTAS developments have strongly influenced the performance of organic syntheses by micro flow (see, e.g., [29]). By this, an overlap with the micro-reactor world was made, which probably will increase more and more. 

J. M., VAN DEN Berg, A. (Eds.), Micro Total Analysis Systems, pp. 661-663, Kluwer Academic Publishers, Dordrecht (2001). 

N., WiDMER, H. M., p-TAS miniaturized total chemical analysis systems, in Proceedings of the Micro Total Analysis System Workshop, pp. 5-27 (Nov. 1994), Enschede, The Netherlands. 

Bergfeld, P. (Eds.), Proceedings of the 2nd International Symposium on Miniaturized Total Analysis Systems,... 

R., Chow, A., Chien, R.-L, Chow, C., Parce, J. W., Commercialized and emerging Lab-on-a-Chip applications, in Ramsey, J. M., van den Berg, A. (Eds.), Micro Total Analysis Systems, pp. 7-9, Kluwer Academic Publishers, Dordrecht (2001). 

D. R., Manz, a.. Micro total analysis systems 2. Analytical standard operations and applications. Anal. Chem. 74,12 (2002) 2637-2652. 

Lindner, D., The pChem Lab project micro total analysis system R D at Sandia National Laboratories, Lab Chip 1 (2001) 15N-19N. 

Micro Total Analysis Systems, pp. 517-518, Kluwer Academic Publishers, Dordrecht (2001). 

Cowen, S. and Craston, D. H., An on-chip miniature liquid chromatography system design, construction and characterization, in Micro Total Analysis Systems, van den Berg and Bergveld, Eds., Kluwer Academic, The Netherlands, 1995, 295. 

The ideal interface is rare. Table 7.3 lists the qualities required for an ideal interface from a chromatographic point of view [3]. Nowadays, hyphenation goes a long way towards total analysis systems (e.g. HPLC-UV-NMR-MS), especially in the pharmaceutical industry. Such magic-wand systems are by no means a panacea for all analytical problems they are more likely to be confined to niche applications. Multihyphenation and multidetector monitoring set their own... 

If total analysis systems are not exactly the best option for polymer/additive analysis, then neither are chip-based hyphenations. The reasons here are completely different minute sample size (homogeneity problems for more traditional samples), and (theoretical) limits to chromatography and concentration-based sensitivity, etc. 

The field of on-chip solution-phase synthesis and analysis, termed pSYN I AS (miniaturized-SYNthesis and Total Analysis Systems) is a rather new field in or-... 

Taylor M.T., Belgrader P., Joshi R., Kintz G.A., Northrup M.A., Fully automated sample preparation for pathogen detection performed in a microfluidic cassette. In Micro Total Analysis Systems 2000, Berg, A. van den, Olthuis, W., Bergveld, P., eds. Kluwer Academic Publishers, The Netherlands, pp 670-672, 2000. 

---