Tolerances exceeded amounts

ACETAMINOPHEN. Acetaminophen is usually well tolerated, and few adverse reactions are seen if die drug is given in recommended amounts. It is important not to exceed die recommended dosage of acetaminophen. If die patient is an alcoholic or chronic user of alcohol, acetaminophen intake is limited to no more tiian 2 g/d. 

When small amounts of hydronium or hydroxide ions are added to a buffer solution, the pH changes are very small. There is a limit, however, to the amount of protection that a buffer solution can provide. After either buffering agent is consumed, the solution loses its ability to maintain near-constant pH. The buffer capacity of a solution is the amount of added H3 O or OH that the buffer solution can tolerate without exceeding a specified pH range. 

There are two common types of heat detectors - fixed temperature and rate of rise. Both rely on the heat of a fire incident to activate a signal device. Fixed temperature detectors signal when the detection element is heated to a predetermined temperature point. Rate of rise detectors signal when the temperature rises at a rate exceeding a pre-determined amount. Rate of rise devices can be set to operate rapidly, are effective across a wide range of ambient temperatures, usually recycle rapidly and can tolerate a slow increase in ambient temperatures without providing an alarm. Combination fixed temperature detectors and rate of rise will respond directly to a rapid rise in ambient temperatures caused by fire, will tolerate a slow increase in ambient temperatures without effecting an alarm, and recycle automatically on a drop in ambient temperature. 

Arsenic recoveries from the zinc column in the range 0.1-5pg ml-1 arsenic exceeded 97%. The concentrations at which certain elements interfere are shown in Table 12.16. Various other elements [A1 m, B m, Ca II, Cd II, Co II, Cr VI, Fe III, K I, Li I, Mg II, Mn H, Na I, Ni II, Pb II, S VI, Sn II and Zn II] showed no significant interference at the 500pg level. Only low senium concentrations in extracts can be tolerated. However, few environmental samples contain appreciable amounts of selenium. As selenium is not reduced to hydrogen selenide on the column, selenium will not interfere in the final determination step, but probably suppresses either arsenic reduction or arsine formation. Selenium appears to suppress arsine generation at high arsenic concentrations but causes a slight enhancement at low arsenic concentrations (around O.lpg), which could not be traced to arsenic impurities in the selenium standard used. 

Until 1994 the EPA regulated pesticides proposed for use on food crops under certain sections of the Food, Drug, and Cosmetics Act. Carcinogenic pesticides were subject to the Delaney clause, and were thus prohibited. The use of a non-carcinogenic pesticide was allowed if its manufacturer provided data sufficient to establish an RfD, and information on expected food residue levels sufficient to document that the RfD would not be exceeded when people consumed food containing residues of the pesticide. The tool for determining compliance with this criterion is called a tolerance, and it is expressed as the maximum amount of a pesticide that can be present in a given amount of food, if the RfD is not to be exceeded. 

Austenitic or duplex stainless steel pressure casing components may be hydrostatically tested with an additional amount of material on areas where machining to critical dimensions and tolerances is required. The additional amount of material shall not exceed 1 mm (0.040 in.) material stock or 5 percent of minimum allowable wall thickness, whichever is less. 

Given the qualitative definitions of the three waste classes, the boundaries of the waste classes would be quantified based on explicit descriptions of how the definitions are related to risk. The boundaries would be expressed in terms of limits on amounts (concentrations) of individual hazardous substances, with specified rules for how to classify waste that contains mixtures of hazardous substances, such as the sum-of-fractions rule for mixtures of substances that induce stochastic effects. Specifically, waste would be classified as exempt if the risk that arises from disposal in a municipal/industrial landfill for nonhazardous waste does not exceed negligible (de minimis) levels. Use of a negligible risk to quantify limits on concentrations of hazardous substances in exempt waste is appropriate because the waste would be managed in all respects as if it were nonhazardous. Nonexempt waste would be classified as low-hazard if the risk that arises from disposal in a dedicated near-surface facility for hazardous wastes does not exceed acceptable (barely tolerable) levels. An essential condition of the definitions of exempt and low-hazard waste is that an acceptable (barely tolerable) risk must be substantially greater than a negligible risk. Waste would be classified as high-hazard if it would pose an unacceptable (de manifestis) risk when placed in a dedicated near-surface facility for hazardous wastes. 

Theoretically, in a simple kinetic resolution the ee value should not exceed 32 % at this specific conversion. In addition to the rhodium complex, this reaction requires acetophenone as stoichiometric hydride acceptor, phenanthroline as coligand and potassium hydroxide as base. An ee value of 98 % at 60 % conversion (theoretical value 67 %)is achieved with [Rh2(OAc)4] without an added base after 3 days. Surprisingly, the enzyme tolerates potassium hydroxide in amounts up to 20 mol% at elevated temperatures however, the enantiomeric excesses are somewhat lower than those obtained in an ordinary kinetic resolution. Unselective, base- or metal-catalyzed acylation might be the reason for the somewhat lower ee value. 

PVC in the feedstock stream in limited amounts can thus be tolerated if a HCl removal process based on calcium hydroxide (slaked lime) injection is used. This is essentially a form of in scrubbing in the pyrolysis reactor itself. This method is used by a number of pyrolysis processes since the fuel oil end products need to be low in chlorine to minimize engine corrosion problems. In the pyrolysis of commingled plastics, lime can be added to the input material and the PVC content reduced down to 2-3% in order to avoid deposits of CaCl2 in pipework. The chlorine content of the final diesel should not exceed 10 ppm. 

Determination of toxicity is based on observation as there is no milligram per kilogram toxic dose established. Ingestion of amounts exceeding maximum daily doses has been tolerated in children. Overdose may result in diuresis with accompanying fluid and electrolyte loss, lethargy, and coma. Clinical effects seen, which are secondary to the fluid and electrolyte loss, include hypotension, tachycardia, contraction alkalosis, muscle weakness, headache, and dysrhythmias. 

Despite the throughput provided by the MUX interface, several practical considerations should be noted. First, the MUX system cannot be used with flow rates that exceed 0.1 mL/min. In addition, a small amount of carryover exists between adjacent sprayers, typically on the order of 0.1%. While each of these issues can be tolerated, the overhead associated with sampling multiple effluent streams limits the number of points that can be acquired across a chromatographic peak. In a four-channel MUX system, each sprayer is accessed about every 1.2 seconds [77]. Thus, to permit the acquisition of 10 data points, the LC peak must be at least 12-seconds wide. Because typical drug-discovery runs include more than one analyte, as well as an internal standard, the MUX system is not truly compatible with fast LC methods that typically produce peak widths less than 6 seconds wide. 

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