Tolazamide

A mixture of 38.6 g (0.1 mol) of 3,4,3, 4 -tetramethoxy-6-(a-acetopropyl)-benzophenone, 5.5 g (0.11 mol) of 100% hydrazine hydrate or 3.52 g (0.11 mol) of hydrazine, and 500 ml of absolute ethanol is boiled for 5 hours. After adding 100 ml of benzene, 400 ml of solvent mixture Is distilled off from the reaction mixture by slow boiling for 3 hours. After cooling for 8 hours, 19 g of 5H-2,3-benzodiazepine derivative are separated from the residue as small, white crystals. The melting point is 133°C to 1 36°C (after recrystallizing from absolute ethanol, 136°C). 

Chemical Name N-[ [(hexahydro-1 H-azepin-1-yl)amino] carbonyl] -4-methylbenzenesulfon-amide 

Chemical Abstracts Registry No. 1156-19-0 Trade Name Manufacturer 

Wright, J.B. U.S. Patent 3,063,903 November 13, 1962 assigned to The Upjohn Company 

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Togaviridae Toilet bowls Toilet preparations Toiletries Toiletry products Tokamaks Tokamax Tolazamide... 

Sulphonylureas Chlorpropamide, glibenclamideb, gliclazide, glimepiride, glipizide, gliquidone, tolazamide, tolbutamide Stimulate insulin secretion (typically 6-24 h) Oral... 

The sulfonylureas appear to lower blood glucose by stimulating the beta cells of the pancreas to release insulin. The sulfonylureas are not effective if the beta cells of the pancreas are unable to release a sufficient amount of insulin to meet the individual s needs. The first generation sulfonylureas (eg, chlorpropamide, tolazamide, and tolbutamide) are not commonly used today because they have a long duration of action and a higher incidence of adverse... 

The oral antidiabetic drugs are contraindicated in patients with known hypersensitivity to tiie drugs, DKA, severe infection, or severe endocrine disease. The first generation sulfonylureas (chlorpropamide, tolazamide, and tolbutamide) are contraindicated in patients with coronary artery disease or liver or renal dysfunction. Other sulfonylureas are used cautiously in patients with impaired liver function because liver dysfunction can prolong the drug s effect. In addition, the sulfonylureas are used cautiously in patients with renal... 

SULFONYLUREAS Acetohexamide (Dymelor), chlorpropamide (Diabinese), tolazamide (Tolinase), and tolbutamide (Orinase) are given with food to prevent gastrointestinal upset. However, because food delays... 

Tolazamide (Y) Tolinase 100, 250, 500 100-250 100 250 1,000 Up to 24 hours Metabolized in liver metabolite less active than parent compound renally eliminated... 

Treatment of piperidine with nitrous acid affords the N-nitroso derivative (190) reduction gives the corresponding hydrazine (191). Condensation of this intermediate with the carbamate (192) obtained from p-toluenesulfonamide leads to the oral hypoglycemic agent tolazamide (193). In a similar vein, reaction of the hydrazine obtained by the same sequence from azepine (194) with the carbamate, 188, gives azepinamide (195). ... 

Thiazinone, synthesis, 280 Thiazosulfone, 141 Thiethylperazine, 382 Thiobarbital, 275 Thiofuradene, 231 Thiopental, 274 Thiopropazate, 383 Thioridazine, 389 Thiothixene, 400 Thonzylamine, 52 Thrombosis, 397 Thyroid gland, 95 Thyroxine, 95, 97 Tolazamide, 137 Tolazoline, 241 Tolbutamide, 136 Tolycaine, 17... 

This drug is also a derivative of first generation of sulfonylurea, and it possesses stimulatory action on 8-cells in pancreas, as well as the same range of action as all other drugs of the group of examined compounds. Tolazamide is used for non-insulin-dependeut diabetes mellitus without expressed microvascular complications. Synonyms of this drug are uor-glycin, tolanase, and others. 

Transferal of Type 2 Diabetes Patients on Insulin to Tolazamide... 

Insulin dose Initial tolazamide dose Insulin withdrawal... 

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