Tolinase - Tolazamide

SULFONYLUREAS Acetohexamide (Dymelor), chlorpropamide (Diabinese), tolazamide (Tolinase), and tolbutamide (Orinase) are given with food to prevent gastrointestinal upset. However, because food delays... 

Tolazamide (Y) Tolinase 100, 250, 500 100-250 100 250 1,000 Up to 24 hours Metabolized in liver metabolite less active than parent compound renally eliminated... 

Tolazamide (Tolinase) is an orally effective hypoglycemic drug that causes less water retention than do the other compounds in this class. 

Tolazamide. Tolazimide (l-(hexahydio-lH-azepin-l-yl)-3-(p-tolysulfonyl)urea), mol wt 311.40, is a white to off-white crystalline powder, odorless or having a slight odor, mp 170—173°C, with a pKa of —3.6 at 25°C and 5.68 at 37.5°C. It is very slightly soluble in water, freely soluble in chloroform, soluble in acetone, and slightly soluble in alcohol. The trade name is Tolinase. 

Tolazamide, U5P. Tolazamide. l-(hexahydrn-l/f-azcpin-l-yl)-3-(/r-tolylsulfonyl)urea (Tolinase). is an analogue of tolbutamide and is reported to be effective, in general, under the same eireumstanccs in which tolbutamide is useful. Tolazamide, however, appears to be more potent than tolbutamide and is nearly equal in potency to chlorpropamide. In studies with radioactive tolazamide, investigators found that 85% of an oral dose appeared in the urine as metabolites that were more soluble than tolazamide itself. 

Thyrostat carbimazole tolazamide Diabewas, Diadutos, Norglycin, Tolanase, Tolinase,... 

Acetohexamide is a blood-glucose-lowering drug of the sulfonylurea class. The first-generation oral hypoglycemic agents include tolbutamide (Orinase), acetohexamide (Dymelor), tolazamide (Tolinase), and chlorpropamide... 

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