Tobramycin ophthalmic ointment

Broad-spectrum antibiotic drops, such as 0.3% tobramycin, 0.3% ciprofloxacin, or the newer generation fluoroquinolones, moxifloxacin or gatifloxacin, may be instilled four times daily to prevent secondary infection as the epithelium heals. A broad-spectrum ophthalmic ointment, such as 0.3% ciprofloxacin, may be instilled into the conjunctival sac at bedtime for prophylaxis. In more pronounced cases, pupillary dilation and cyclo-plegia with a long-acting agent such as 5% homatropine may help to relieve pain from associated ciliary spasm. 

Tobramycin is available in ophthalmic ointments and solutions. Tobramycin (1 mg/kg initially, to be adjusted thereafter) is indicated in the treatment of ... 

The antimicrobial activity, pharmacokinetic properties, and toxicity profile of tobramycin (nebcin) are very similar to those of gentamicin. Dosages and serum concentrations are identical with those for gentamicin. Tobramycin (tobrex) also is available in ophthalmic ointments and solutions. 

Tobramycin is available as a topical ophthalmic solution and an ointment (see Table 11-5). Tobramycin is also prepared as a topical fortified solution for the treatment of corneal ulcers and is used in place of fortified gentamicin using the same dosage schedule (see Table 11-1). 

Small corneal abrasions typically heal quickly (24 to 36 hours). Topical prophylactic antibiotic therapy protects the disrnpted corneal epithelium from secondary infection as the tissne heals. Broad-spectrum ophthalmic antibiotic drops, snch as 0.3% tobramycin or 0.5% moxi-floxacin, may be instilled four times daily, along with a broad-spectrnm antibiotic ointment such as 0.3% tobramycin or 0.3% ciprofloxacin instilled at bedtime. Prophylactic topical antibiotic therapy can be discontin-ned once the corneal epithelium has healed. 

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