Tissue transplantation hyperacute rejection

Hyperacute rejection may occur when preformed donor-specific antibodies are present in the recipient at the time of the transplant and may be evident within minutes of the transplant procedure. Hyperacute rejection can be induced by immunoglobulin G (IgG) antibodies that bind to antigens on the vascular endothelium, such as class I MHC, ABO, and vascular endothelial cell antigens. Tissue damage can be mediated through antibody-dependent, cell-mediated cytotoxicity or through activation of the complement cascade. The ischemic damage to the microvasculature rapidly produces tissue necrosis. 

General Considerations - The spectrum of potential clinical uses for an effective compound In this area Is continuing to broaden. During the past year a number of reports have appeared which tend to substantiate the role of FA In the hyperacute rejection of tissue transplants. It has been known for some time that antigen-antibody complexes are capable of aggre-... 

Oriol R, Ye Y, Koren E, Cooper DKC. Carbohydrate antigens of pig tissues reacting with human natural antibodies as potential targets for hyperacute vascular rejection in pig-to-man organ xenotransplantation. Transplantation 1993 56 1433-1442... 

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