Potential clinical uses

The aim of this review is to summarize the available pharmacology and safety data on this nonsystemic antibiotic as well to outline its current and potential clinical use. 

Pelosini I, Scarpignato C Rifaximin, a peculiar rifamycin derivative Established and potential clinical use outside the gastrointestinal tract. Chemotherapy 2005 51(suppl 1) 122— 130. 

Rifaximin, a Peculiar Rifamycin Derivative Established and Potential Clinical Use Outside the Gastrointestinal Tract... 

Deans, R.J. and Moseley, A.B. (2000) Mesenchymal stem cells Biology and potential clinical uses. Exp Hematol 28, 875-884. 

Much of the preclinical work with a new compound deals with so-called animal models, i.e. experimental set-ups thought to provide relevant information on the mechanism of action of a drug and to allow predictions about its potential clinical use. Sections 4. 5 and 4. 6 of this chapter provide descriptions of typical models used in many of these studies. Although some of these models are based upon hypotheses concerning the mechanisms of action of existing psychopharmaceuticals, the emphasis of these sections is on behavioral models that appear to be of greatest interest in the current context. 

Consequently, a substrate such as secopandoline (220), with opposite configuration at C-14, should lead to bisindole bases having the desired (16 S) configuration, and since this configuration appears to be vital for pharmacological activity, such a reaction may well afford a route to new compounds of potential clinical use. The condensation of the chloroindolenine from (220) with vindoline gave, as expected, the vinblastine isomer (221) as shown in Scheme 27 it is of interest to note that this base is also isomeric with vincovaline (vide supra), but is not identical with it 124 if the stereochemistry deduced for these bases is correct, vincovaline (199) is epimeric with the new base (221) at C-16 and possibly also at C-20. ... 

Cannabinoids may share at least some common neuronal mechanisms with opioid compounds. Studies of intracellular events associated with ligand binding to either cannabinoid or opiate receptors indicate that these receptors are linked via G proteins to the production of cAMP. Certain studies have also indicated that there may be some interaction between cannabinoid binding sites and opiate receptors in the reward pathway. In addition, there is increasing evidence that cannabinoids interact with opiate systems involved in the perception of pain. In fact, cannabinoids clearly produce analgesic effects in both experimental animals and humans, and of all the potential clinical uses of cannabinoids, the mediation of analgesia has received the most attention. Some evidence also indicates that the cannabinoid receptor system is an analgesic system. 

Wharton RN, Perel JM, Dayton PG, Malitz S. A potential clinical use for methylphenidate with tricyclic antidepressants. Am J Psychiatry 1971 127(12) 1619-25. 

Various nonsteroidal anti-inflammatory drugs (NSAIDs) have been studied for potential clinical use in allergic conjunctivitis. Specifically, ketorolac tromethamine 0.5% has been found to be beneficial in treating SAC and is currently the only NSAID approved for topical treatment of SAC. 

Selective kinase inhibitors are invaluable tools to dissect the physiologic and pathophysiologic roles of protein kinases, to identify new substrates, to identify model systems that allow evaluation of potential clinical use, and importantly, to develop new therapeutic agents. 

Human superoxide dismutase has been prepared in large quantities by recombinant DNA methods in Escherichia coli. It has potential clinical use in preventing oxygen toxicity, for example, during the reestablishment of blood flow through dissolution of a blood clot by thrombolytic... 

Potential Clinical Uses of SARMs 8.4.3.1 Cancer Cachexia... 

J.R., Heck, J. V., Smith, R.G., Moller, D.E., 1999. Science, 284, 974-977] suggests that a similar strategy could be used for IGF-I and the IGF-I receptor leading to the characterization of IGF-I mimics of potential clinical usefulness. 2000 Elsevier Science B.V. All rights reserved. 

The above results tend to support the proposal that caeruloplasmin, or an enzyme with similar properties, plays an important role in the maintenance of normal mental function and that interference with this enzyme leads to the appearance of abnormal mental states. It is not possible at present, however, to draw any firm conclusions regarding the effects of a compound on caeruloplasmin and its potential clinical usefulness in the treatment of mental disorders. Such conclusions must await the results of further studies which the present work has shown to be desirable. 

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