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Tissue regeneration growth factor presentation

The role of the CO/HO axis in the control of cell proliferation and differentiation is still very poorly explored. Likewise, wound healing and tissue regeneration are two scientific niches where CO must be studied with much attention. There are few data about the role of CO on cellular proliferation/differentiation and most of the published data concern HO activity. HO-1 and HO-2 are involved in cornea wound healing HO-1 induction accelerates wound healing after epithelial injury [96] and deletion of HO-2 impairs re-epitheliaUzation delaying the repair response [97]. In the hepatic model, mice treated with CO presented higher levels of hepatocytic proliferation and enhanced expression of hepatocyte growth factor (HGF) after hepatectomy [98]. [Pg.204]

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See also in sourсe #XX -- [ Pg.16 , Pg.16 ]



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