Tissue regeneration adhesive peptides

A scaffold material can provide cues that will direct and control the cell-matrix interactions to promote and regulate tissue regeneration. Biochemical signals such as matrix proteins, adhesive peptides, and growth factors can be incorporated into a material by nonspecific adsorption or through covalent immobilization. Since many mammalian cells require adhesion for cell viability, these molecules can provide the essential cues for cell attachment. 

Neurite extension can be controlled using immobilized peptides. RGD peptides linked to PLXA-PEG-biotin surfaces via a stieptavidin linker were shown to spatially control the adhesion and the direction of neurite extension from PC12 cells (Patel et al., 1998). Neurite extension from PC12 cells and NG108-15 neuroblastoma cells was also spatially controUed using laminin-derived peptides YIGSR and KVAV bound to fluorinated ethylene propylene films (Ranieri et al., 1994). These smdies demonstrate the potential impact of peptides on die regeneration of nerve tissues. 

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