Thyrotropin-releasing hormone resistance

H. Bundgaard, J. Mpss, Prodrugs of Peptides. 6. Bioreversible Derivatives of Thyrotropin-Releasing Hormone (TRH) with Increased Lipophilicity and Resistance to Cleavage by the TRH-Specific Serum Enzyme , Pharm. Res. 1990, 7, 885-892. 

Lithium Plus Thyroid Supplementation. Treatment-resistant and rapid-cycling bipolar patients may have an increased frequency of thyroid dysfunction. Further, some patients suffer from subclinical hypothyroidism and improve with the addition of thyroid supplementation. In this context, several case reports involving this population found that high doses of the thyroid hormone levothyroxine sodium (T ) were clinically beneficial (122,123 and 124). Kusalic (1.25) found that 6 of 10 rapid cyclers had hypothyroidism, based on their thyrotropin-releasing hormone stimulation tests. Further, the average number of mood episodes per year decreased by more than 75% (i.e., from 9.7 to 2.2) after thyroxine was added to the treatment regimen. 

Bundgaard H, Moss J Prodrug of peptides. 6. Bioreversible derivatives of thyrotropin-releasing hormone (TRH) with increased lipophili-city and resistance to cleavage by TRH-specific serum enzymes, Pharm Res 1990, 7, 885-892. 

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