Thyrotropin releasing hormone receptor

Heuer H., Schafer M., ODonnell D., Walker P., Bauer K. (2000). Expression of thyrotropin-releasing hormone receptor 2 (TRH-R2) in the central nervous system of rats. J. Comp. Neurol 428, 319-26. 

Zhu, C. C., Cook, L. B., and Hinkle, P. M. (2002) Dimerization and phosphorylation of thyrotropin-releasing hormone receptors are modulated by agonist stimulation. J. Biol. Chem. 277,28228-28237. 

Gershengorn MC, Osman R (1996) Molecular and cellular biology of thyrotropin-releasing hormone receptors. Physiol Rev 76 175-191. 

Harvey, S. Benzodiazepine antagonism of thyrotropin-releasing hormone receptors biphasic actions on growth hormone secretion in domestic fowl. J. Endocrinol. 137 35-42, 1993. 

Jinsi-Parimoo, A., Gershengom, M.C., 1997. Constitutive activity of native thyrotropin-releasing hormone receptors revealed using a protein kinase C-responsive reporter gene. Endocrinology 138, 1471-1475. 

Perlman, J.H., Colson, A.O., Wang, W, Bence, K., Osman, R., Gershengom, M.C. Interactions between conserved residues in transmembrane helices 1, 2, and 7 of the thyrotropin-releasing hormone receptor, J. Biol. Chem. 1997,272(18), 11937-42. 

Johnson, W., et al. (1984). Solubilization and Characterization of Thyrotropin-releasing Hormone Receptors... 

Hinkle, P.M. and Goh, K.B.C. (1982) Regulation of thyrotropin releasing hormone receptors and responses by l-triiodothyronine In dispersed rat pituitary cell cultures. Endocrinology 110 1725. 

Banerji, A. and Prasad, C. (1982) The postnatal development of the pituitary thyrotropin releasing hormone receptor in male and female rats. Endocrinology 110 663. 

The BZ stmcture also has provided a molecular scaffold for a number of peptide receptor ligands (26). Antagonists for the cholecystokinin (CCK-A) receptor, eg, devazepide (65), the thyrotropin-releasing hormone (TRH) receptor, eg, midazolam (66), and the /i -opiate receptor, eg, tifluadom (67), as well as a series of ras famyl transferase inhibitors, eg, BZA-2B (68) (30) have been identified (Table 4). 

Prolactin is an essential hormone for normal production of breast milk following childbirth. It also plays a pivotal role in a variety of reproductive functions. Prolactin is regulated primarily by the hypothalamus-pituitary axis and secreted solely by the lactotroph cells of the anterior pituitary gland. Under normal conditions, secretion of prolactin is predominantly under inhibitory control by dopamine and acts on the D2 receptors located on the lactotroph cells. Increase of hypothalamic thyrotropin-releasing hormone (TRH) in primary hypothyroidism can stimulate the release of prolactin. 

Dupre SM, Guissouma H, Flamant F, et al. Both thyroid hormone receptor (TR) beta 1 and TR beta 2 isoforms contribute to the regulation of hypothalamic thyrotropin-releasing hormone. Endocrinology. 2004 145 2337-2345. 

Tagging and recovery of associated proteins, as in RNA-TRAP also thrombin receptor activation peptide Thyroid hormone response elements Thyrotropin-releasing hormone... 

Conformational restriction is a very powerful method for probing the bioactive conformations of peptides. Small peptides have many flexible torsion angles so that enormous numbers of conformations are possible in solution. For example, a simple tripeptide such as thyrotropin-releasing hormone (TRH 7) (Fig. 15.4) with six flexible bonds could have over 65,000 possible conformations. The number of potential conformers for larger peptides is enormous, and some method is needed to exclude potential conformers. Modem biophysical methods, e.g., X-ray crystallography or isotope edited nuclear magnetic resonance (NMR), (33) can be used to characterize peptide-protein interactions for soluble proteins, but most biophysical methods cannot yet determine the conformation of a ligand bound to constitutive receptors, e.g., G-protein-coupled receptors (34, 35). 

TR 82, TR/31, TRal thyroid hormone receptors TRH thyrotropin-releasing hormone TSAb thyroid-stimulating antibody TSH thyroid-stimulating hormone... 

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