Thyroid inhibitor

D-Camitine 14 L-Carnitine Thyroid inhibitor Multi-enzymatic pathway Agrobacterium sp. Single-stage fermentation of four processes [7]... 

The answers are 450-a, 451-b, 452-b. (Katzung, p 652. Hardman, pp 1397—1406.) Agents that can interfere directly or indirectly with the synthesis of thyroid hormone are called thyroid inhibitors. Perchlorate, an ionic inhibitor, interferes with the ability of the thyroid to concentrate F by acting as a competitive inhibitor. It is used in patients with iodide-induced hypothyroidism, such as can occur with the antiarrhythmic agent amio-darone. 

Triiodothyronine is not classified as a thyroid inhibitor it is an amino acid derivative of thyronine and results from the oxidative coupling of monoiodotyrosyl and diiodotyrosyl residues. Iodine 131, the most often used radioisotope of I, is rapidly absorbed by the thyroid and is deposited in follicular colloid. Prom the site of its deposition, Bll causes fibrosis of the thyroid subsequent to pyknosis and necrosis of the follicular cells. 

Marty MS, Crissman JW, Carney EW (2001) Evaluation of the male pubertal assay s ability to detect thyroid inhibitors and dopaminergic agents. Toxicol Sci 60 63-76 Newbold RR (1999) Hormonal Mechanisms in Female Reproductive Tract Toxicity In Harvey PW, Rush KC, Cockbum A (eds) Endocrine and Hormonal Toxicology. John Wiley Sons, England, pp 407-418... 

Several uracil derivatives have been developed as drugs. Thus, methyl-thiouracil and propylthiouracil are thyroid inhibitors Bucolome is an antiinflammatory and Uramustine (Uracil Mustard), Fluorouracil, and its masked compounds are anticancer agents. Aminometradine and Amiso-metradine are used clinically as diuretics, and Urapidil and Ketanserin are used as antihypertensives (Scheme 5). 

Thyroid Inhibitors of T3-monodeiodinase (converts T4 to T3) Liver enzyme inducers (increase disposition of thyroid hormones)... 

Use Intermediate in synthesis of sulfathiazole, medicine (thyroid inhibitor). 

DL-Form, efflorescent prisms, platelets from water probably contg 1 mol water of crystn. Dec at about 245. Aq solns are acid to litmus. Behaves as a monobasic acid when titrated with NaOH and phenolphthalein. One gram dissolves in about 590 ml water at 20. therap CAT Thyroid inhibitor. 

Pale yellow needles from water, mp 180. Sol in about 88 parts hot water, in ethanol, chloroform, ether, acetone, ammonia, alkalies. Sparingly so) in toluene. Practically insol in benzene. Note This is a controlled substance (depressant) listed in the U.S. Code of Federal Regulations, Title 21 Part 1308.13 (1987). therap cat Thyroid inhibitor-... 

CPL 46 EINECS 231-511-9 HSDB 5038 Irenat KM Sodium Perchlorate Natriumperchloraat Natriumper-chlorat Perchlorate de sodium Perchloric acid, sodium salt Sodio (perclorato di) Sodium (perchlorate de) Sodium perchlorate UN1502. Used in explosives has been used medicinally as a thyroid inhibitor. Crystals.dec about 130° d = 2.02. Kerr-McGee. 

Production of L-carnitine by microbial hydroxylation of y-butyro-betaine (continuous process, yield > 130 g 1— 1 d 1, or repeated batch process) with amutant strain of Agrobac-terium/Rhizobium lacking L-carnitine dehydrogenase.This process (Fig. 17), developed by Lonza, operates on a 140 tons per year scale. L-Carnitine is used in pharmaceuticals as a thyroid inhibitor, as a slimming aid, and in sports foods and drinks [174,176,177]. 

Pathological effects on nerve cells and the liver.1.9-9.9 mg is thyroid inhibitor in rats. ... 

Hazardous Decomp. Prods. Heated to decomp., emits toxic fumes of CO, CO2, NOx, SOx Storage Store refrigerated keep tightly closed store away from min. acids and bases Uses Intermediate in synthesis of sulfathiazole medicine (thyroid inhibitor) prep, of azo dyes Manuf./Distiib. Acres Org. http //www.acros.be, Aldrich http //www.sigma-aldrich.com, Alfa Aesar http //www.alfa.com, Fluka http //www.sigma-aldrich.com, ICN Biomed. Research Prods, http //www.icnbiomed.com Lancaster Synthesis Oakwood Prods. http //www.oakwoodchemicai.com, Pfaltz Bauer http //www.pfaitzandbauer.com. Spectrum Quality Prods. http //www.spectrumchemicai.com, TCI Am. http //www.tciamerica. com... 

Asymmetric synthesis can also sometimes be done by biocatalysis. This has been used in large-scale syntheses for years. For example, the Reich-stein process for the synthesis of vitamin C, established in 1933 and still in use, involves the biotransformation of sorbitol to L-sorbose [41]. L-camitine is used as a thyroid inhibitor. It is prepared by enzymatic hydroxylation of 4-butyrobetaine [42]. 

The use of the thyroid inhibitors to induce considerable weight gain through augmented water retention is both fraudulent and undesirable for safety reasons. The thiouracils may be detected at the 1 mg/kg level by UV irradiation after TLC. More sensitive methods involving derivatisation to form fluorescent compounds followed by TLC or HPLC are also available with limits of detection of the order of 10 fig/kg. The main problem in the field of hormone residue analysis is the lack of general procedures for multiple residue detection the demands placed on the analyst by EEC proposals provide a stimulus towards further development. 

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