Thyroid diagnosis

Iodine 131 8 days Beta and gamma Thyroid diagnosis and treatment... 

I25j 59.41 d 7 (35, 179) Biochemistry (thyroid) Diagnosis (thrombosis, kidney function)... 

Figure 52-8 Strategies for thyroid diagnosis using a sensitive TSH assay as the initial step. (Modified from Klee GG, Hay ID. Assessment of sensitive thyrotropin assays for an expanded role in thyroid fiinction testing Proposed criteria for analytic performance and clinical utility, j Clin Endocrine/ Metab 1987 3 461-71. Copyright 1987,The Endocrine Society.)...

Thyroid Diagnosis - Thyroid Clinic Thyroid Diagnosis - Thyroid Clinic Thyroid Diagnosis - Thyroid Clinic 1967 - 1991 Thyroid Function 1986 - 1991 1967 - 1991 (pathological entity)... 

Use of measurement of blood thyroxine or thyroid-stimulating hormone (TSH) in the neonatal diagnosis of congenital hypothyroidism. 

Methodology. Several radioimmunoassays of human calcitonin (hCT) have been developed In the past 5 years (18-20). Their greatest utility has been In the definitive diagnosis of patients with medullary carcinoma of the thyroid gland (MTC) and, recently. In Identifying family members of these patients who have occult MTC. 

Early Diagnosis of Medullary Carcinoma of the Thyroid Gland... 

D. Coomans, M. Jonckheer, D.L. Massait, I. Broeckaert and P. Blockx, The application of linear discriminant analysis in the diagnosis of thyroid diseases. Anal. Chim. Acta, 103 (1978) 409-415. 

Criteria for diagnosis Five or more attacks fulfilling the above criteria are necessary for diagnosis Laboratory assessments that may be helpful in excluding medical comorbidities Complete blood cell count (CBC), chemistry panel, thyroid function tests, erythrocyte sedimentation rate (ESR)... 

Approximately one-third of patients with MDD do not respond satisfactorily to their first antidepressant medication.37 In such cases, the clinician must evaluate the adequacy of antidepressant therapy, including dosage, duration, and patient compliance.17 Treatment reappraisal also should include verification of the patient s diagnosis and reconsideration of clinical factors that could be impeding successful therapy, such as concurrent medical conditions (e.g., thyroid disorder), comorbid psychiatric conditions (e.g., alcohol abuse), and psychosocial issues (e.g., marital stress).16... 

O In most patients with thyroid hormone disorders, the measurement of a serum thyroid-stimulating hormone (TSH) level is adequate for the diagnosis of hypothyroidism and hyperthyroidism. The target TSH for most patients being treated for thyroid disorders should be the mean normal value of 1.4 milliunits/L or 1.4 microunits/mL (target range 0.5-2.5 milliunits/L or 0.5-2.5 microunits/mL). 

Lahr G, Sticha M, Schtitzea K, et al. Diagnosis of papillary thyroid carcinoma is facilitated by using an RT-PCR approach on laser-microdissected archival material to detect RET oncogene activation. Pathobiology 2000 68 218-226. 

A 2.%i fear-old female complains of increasing anxiety and restlessness. Physical examination reveals tachycardia and tremors. Palpation of the neck reveals a 3-cm nodule on her thyroid gland. While awaiting laboratory confirmation of the diagnosis, she is given a drug that diminishes her tachycardia and tremors. 

The diagnosis of menopause should include a comprehensive medical history and physical examination, complete blood count, and measurement of serum FSH. When ovarian function has ceased, serum FSH concentrations exceed 40 international units/L. Altered thyroid function and pregnancy must be excluded. 

Laboratory tests Laboratory tests useful in the diagnosis and evaluation of thyroid function are listed in the following table, indicating the alterations noted in various hyroid disorders. ... 

A 36-year-old white woman is noted to have a 1.5-cm nodule in the right lower lobe of her thyroid on routine examination. Her thyroid functions are normal and a uptake and scan of the thyroid produce normal findings. Her serum calcium levels were determined to be 14 mg/dL (normal levels 9 to 10.3 mg/dL). What is the most likely diagnosis ... 

A. Although all of the conditions can present as an asymptomatic nodule in the thyroid, the marked hypercalcemia in this patient makes hyperparathyroidism the probable diagnosis. Carcinomas of the thyroid are common, and outcomes are improved with early diagnosis. Medullary carcinoma and hyperparathyroidism caused by hyperplasia may be inherited and are associated with the multiple endocrine neoplasia syndromes. 

A normal response is an increase in plasma TSH of 5 to 15 pU/mL above baseline. A response of less than 5 pU/mL above baseline is generally considered to be blunted (some laboratories consider a response below 7 pU/mL to be blunted) and may be consistent with a major depression. An abnormal test is found in approximately 25% of patients with depression. A blunted TSH response (especially in conjunction with an abnormal DST) may help in confirming the differential diagnosis of a major depressive episode and support continued antidepressant treatment. An increased baseline TSH or an augmented TSH response (higher than 30 pU/mL), in conjunction with other thyroid indices, might identify patients with hypothyroidism, mimicking a depressive disorder. These patients may benefit most from thyroid replacement therapy. 

The etiology and pathogenesis of hypothyroidism are outlined in Table 38-5. Hypothyroidism can occur with or without thyroid enlargement (goiter). The laboratory diagnosis of hypothyroidism in the adult is easily made by the combination of a low free thyroxine and elevated serum TSH (Table 38-2). 

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