Thrombus deposition

Two critical discoveries were made in this direction, largely at the State University of New York s Down State Medical Center. (1) Both the blood corpuscles that form thrombus deposits and the arterial walls in a healthy person are negatively charged, i.e., repelling and there is no thrombus formation. (2) In arteriosclerosis, the sign of one of these charges changes. 

Table 17.2, Dependence of thrombus deposition at metal electrodes on position of metals in the electrochemical series (adapted from Ref. 23...

Metal M"+/M standard electrode potential (vs. NHE) Rest potential at metal-blood interface (vs. NHE) Occurrence (/) or non-occurrence (x) of thrombus deposition... 

Massachusetts Institute of Technology and his Ph.D. in chemical engineering at Princeton University. While at Princeton, his research was directed by Arthur V. Tobolsky in the area of polymer physical chemistry. He is currently professor of chemical engineering at the University of Wisconsin where, since 1967, he has been active in polymer research. He has published more than 80 papers on topics covering polyurethane block polymers, inomers, polymer yield mechanisms, composites, and fiber physics. His current research includes studies of protein and thrombus deposition on polymers used in biomedical applications. Professor Cooper is a Fellow of the American Physical Society and has served on the Board of Trustees of Argonne Universities Association. 

The various carbohydrate components of adsorbed glycoproteins may play an important role in the recognition of the biomaterial as foreign and in the subsequent events leading to thrombus deposition. 

Figure 19. Albumin-coated PVC after 5 min of blood contact. This blood contact time represents the maximum thrombus deposition as measured by radioisotope-labeled fibrinogen and platelets. No large adherent thrombi...

Figure 2 shows that similar adsorption phenomena are exhibited by lysozyme and albumin. Related work seems to suggest that polymers that contain a certain balance of hydrophobic and hydrophilic chemical groups show minimized biological interaction (for example, low protein adsorption, low thrombus deposition, and low platelet consumption) (6). The adsorption of radiolabeled IgG, however, was maximal at intermediate copolymers. This result has a number of implications with respect to both the fundamental adsorption mechanism and the biocompatibility of these materials. 

Chesebro, H.J., Lam, J.Y.T. and Fuster, V. (1986). The pathogenesis and prevention of aortocoronary vein bypass graft occlusion and restenosis after arterial angioplasty role of vascular injury and platelet thrombus deposition. ]. Am. Coll Cardiol, 8, 57B-66B... 

The blood clot formed in a test tube is strikingly different from a thrombus deposit formed in vivo in the vascular system. A clot in a test tube consists of a fibrin network in which red cells, white cells, and relatively small numbers of platelets are found. On the other hand, an in vivo thrombus deposit consists of large amorphous masses of platelets, surrounded by white cells with a few red cells. However, it is possible to form deposits closer to thrombi rather than to blood clots in vitro by using circulating plastic loops in which the blood is in motion during coagulation. ... 

To confirm the dependence of thrombus deposition on the potential across an electrode-blood interface, a series of similar experiments were carried out with platinum wire electrodes, inserted into the canine carotid and femoral arteries and maintained at several values of potentials between 1 and +1... 

Dependence of Thrombus Deposition at Metal Electrodes on Position of Metal in... 

Lelah MD, Lambrecht LK, Cooper SL. A canine ex vivo series shunt for evaluating thrombus deposition on polymer surfaces. J Biomed Mater Res 1984 18 475-96. 

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