Thrombospondin cell adhesion

Sage E Regulation of interactions between cells and extracellular matrix a command performance on several stages. J Clin Invest 2001 107 781. (This article introduces a series of six articles on cell-matrix interaction. The topics covered are cell adhesion and de-adhesion, thrombospondins, syndecans, SPARC, osteopontin, and Ehlers-Danlos syndrome. All of the articles can be accessed at www.jci.org.)... 

Narizhneva NV Razorenova OV Podrez EA, et al, Thrombospondin-1 up-regulates expression of cell adhesion molecules and promotes monocyte binding to endothelium, FASEBJ 2005 19 1 158-1 160. 

The second approach includes native long chain of ECM proteins as well as short peptide sequences derived from intact ECM proteins that are able to interact specifically with cell receptors and to confer appropriate functions to the biomaterials [102]. The most studied class of cell-adhesive molecules comprises ECM-soluble serum proteins, including fibronectin (FN), vitronectin (VN), collagen families, thrombospondin, osteopontin, fibrinogen, von Willebrand factor and laminin (LN) [87]. 

Gantt SM, Clavijo P, Bai X, Esko JD, Sinnis P (1997) Cell adhesion to a motif shared by the malaria circumsporozoite protein and thrombospondin is mediated by its glycosaminoglycan-binding region and not by CSVTCG. J Biol Chem 272 19205-13. 

Sickle erythrocytes have increased surface expression of CD36. Microvascular endothelial cells do express CD36. Adhesion between these CD36 molecules of the two cells types can be mediated via the bridging ligand thrombospondin". Indeed plasma thrombospondin levels are increased in SCA patients with pain crisis [15]. 

Houdijk WP, de Groot PG, Nievelstein PF, Sakariassen KS, Sixma U Subendothelial proteins and platelet adhesion, von Willdvand factor and fibronectin, not thrombospondin, are involv in platelet adhesion to extracellular matrix of human vascular endothelial cells. Arteriosclerosis 6 24-33,1986. 

Tua nsld GP, Rothman VL, Murphy A, Siegler K, Smith L, Smith S, Karczewski J, Knudsen KA Thrombospondin promotes cell>substratum adhesion. Science 236 1570-1573,1987. 

At least 12 receptors CD 36, ICAM-1, PECAM-1/CD31, ELAM, thrombospondin (TSP), VCAM, E-selectin, chondroitin sulphate A (CSA), HA and alpha V/beta 3 integrin (Siano et al., 1998) on endothelial cells and HS, CR1 (CD35), blood group antigen A on red cells (see reviews by Sherman et al., 2003 and Cooke et al., 2004b) have been identified in the adhesion of P. falciparum-infected red cells to the vascular endothelium (sequestration/cytoadherence) and to erythrocytes (resetting). 

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