Thioxanthene derivatives

Substituted dibenzo[6,/]thiepins can be generated from thioxanthene derivatives by the rearrangement of carbocation 1. Compared with other possible cations, the tropylium ion type 1C is favored because of its resonance energy. Depending on the reaction conditions, the thiepin cation can react to give thiepins by loss of a proton, or by trapping a nucleophile, followed by elimination. 

Thioxanthene derivatives flupenthixol decanoate flupenthixol dihydrochloride thiothixene zuclopenthixol acetate zuclopenthixol decanoate zuclopenthixol dihydrochloride... 

In my opinion, one may assume a priori that these criteria will not be fulfilled first, if the dopamine-sensitive adenylate cyclase was really involved in the parathormone secretion, the patients treated with neuroleptics and especially with the most potent drugs on the sites (phenothiazine and thioxanthene derivatives) would have normally revealed marked changes in their parathormone secretion, just like as is the case for the prolactin secretion in fact such changes have never been observed secondly, a recent report clearly indicates that the injection of dopamine in man does not modify parathormone secretion although a marked decrease in prolactin was observed (21). There is no receptor without physiological response the study of receptor requires a multidisciplinary approach. 

Various substituted naphtho[2,l-f>]thiopyran-l -ylidene-9H-thioxanthene derivatives 23 have been synthesised using diazo-thioketone coupling as the key step. The compounds function as light-driven molecular motors and studies of the photochemical and thermal isomerisation processes indicate a four-step unidirectional 360° rotation about the double bond of the upper half of the molecule with respect to the lower half <02JA5037>. 

Phenothiazine derivatives (e.g., chlorpromazine) Thioxanthene derivatives (e.g., thiothixene) Butyrophenone derivatives (e.g., haloperidol) Dihydroindolone derivatives (e.g., molindone) Dibenzoxazepine derivatives (e.g., loxapine) Atypical neuroleptics (e.g., sulpiride, pimozide, and clozapine)... 

Dopamine-receptor antagonists having antipsychotic properties, such as phenothiazine, butyrophenone, and thioxanthene derivatives, and Gl-stimulant drugs, such as metoclopramide, are contraindicated with pergolide. The... 

Table 22.1. Phenothiazine and the Thioxanthene Derivatives Used as Neuroleptics ...

More than 24 phenothiazine and the reiated thioxanthene derivatives are used in medicine, most of them for psychiatric conditions. The structures, generic and trade names, dose, and side effects of phenothiazines and thioxanthenes currentiy used as neuroieptics are iisted in Tabie 22.1. 

When thioxanthene derivatives that contain an olefinic double bond between the tricyclic ring and the side chain... 

The synthesis and pharmacology of a series of 2-hyd gxy and 2-alkoxy thioxanthene derivatives has been described. Additional phenothiazines related to 15f substituted with an alkypiperidyl group were jlso prepared and reported to have CNS depressant activity. 

Other papers on thioxanthene derivatives deal with the methylation, on sulphur and sulphoxide-oxygen respectively, of thioxanthene and thio-xanthone sulphoxide, the Beckmann rearrangement of thioxanthone oxime, and the quantitative reduction of thioxanthene sulphoxide to thioxanthene with sodimn borohydride-cobalt chloride, a reagent which appears to be of fairly neral applicability. ... 

Reviews have appeared on thiopyrans, thiopyrylium salts, and thio-chromanones and related compounds. Biological aspects of some thioxanthone drugs and other thiop3rran derivatives have been reviewed. Space limitations preclude citation of the patent literature, but it should be noted that many patents have appeared that are concerned with juvenile-hormone intermediates and with biologically active thioxanthene derivatives. 

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