Flupenthixol decanoate

Fluphenazine decanoate, Pipothiazine palmitate, FFaloperidol decanoate, Flupenthixol decanoate, Clopenthixol decanoate Psychosis... 

Across the sites, an average of 15% of inpatients received depot antipsychotic drugs (Sim etal, 2004b). This was most common in Singapore (75%) followed by Taiwan (20%), Japan and China (6%). The depot antipsychotic drugs used were fluphenazine decanoate, flupenthixol decanoate, zuclopenthixol decanoate, haloperidol decanoate, pipothiazine palmitate, and fluphenazine enanthate. 

Quraishi S, David A. Depot flupenthixol decanoate for schizophrenia or other similar psychotic disorders. Cochrane Database Syst Rev 1999. Issue 4. 

Thioxanthene derivatives flupenthixol decanoate flupenthixol dihydrochloride thiothixene zuclopenthixol acetate zuclopenthixol decanoate zuclopenthixol dihydrochloride... 

Johnson DAW, Ludlow JM, Street K, et ai. Double-blind comparison of half-dose and standard-dose flupenthixol decanoate in the maintenance treatment of stabilised outpatients with schizophrenia. Br J Psychiatry 1987 151 634-638. 

Wistedt B. A depot neuroleptic withdrawal study. A controlled study of the clinical effects of the withdrawal of depot fluphenazine decanoate and depot flupenthixol decanoate in chronic schizophrenic patients. Acta Psychiatr Scand 1981 64(l) 65-84. 

Disposition in the Body. Readily absorbed after oral administration bioavailability about 55%. Flupenthixol decanoate is very slowly absorbed from the site of intramuscular injection. Peak plasma concentrations are attained about 3 to 6 hours after oral administration and 3 to 7 days after intramuscular injection. The main metabolic reactions are sulphoxidation, side-chain N-dealkylation and glucuronic acid conjugation. AT-Desalkylflupen-thixol and flupenthixol sulphoxide are the major metabolites found in plasma (both are inactive). Numerous metabolites are excreted in the urine and faeces and there is evidence of enterohepatic circulation. 

Fusidic Acid 588.8 Flupenthixol Decanoate 719.8 Rifamycin Sodium... 

Fluoxymesterone, 627 Flupenthixol, 628 Flupenthixol decanoate, 628 Flupenthixol hydrochloride, 628 Flupenthixol sulphoxide, 628 Fluphenazine, 629 Fluphenazine decanoate, 629 Fluphenazine enanthate, 629 Fluphenazine heptanoate, 629 Fluphenazine hydrochloride, 629 Fluphenazine sulphoxide, 629 Flurandrenolide, 630 Flurandrenolone, 630 Flurazepam, 630 Flurazepam dihydrochloride, 630 Flurazepam hydrochloride, 630 Flurazepam monohydrochloride, 630 Flurazepamylacetic acid, 631 Flurbiprofen, 631 Flurogestone, 623 Fluspirilene, 632 Fluvet, 623 FML, 627 Folacin, 633 Folasic, 633 Foldine, 633... 

When the occurrence of flip-flop kinetics is not recognised it may compromise the interpretation of results from studies on the pharmacokinetic behaviour of slow release dosage forms. Flip-flop pharmacokinetics may occur with any extravascularly administered parenteral slow release dosage form. Intramuscular depot injectimis of antipsychotics such as fluphenazine decanoate, haloperidol decanoate or flupenthixol decanoate show this behaviour. It also occurs after the administration of oral slow release products of active substances such as isoxuptine, carbamazepine, diclofenac, valproic acid, morphine and theophylline. 

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