Pseudo-parkinsonism

Adverse effects. Disorders of extra-pyramidal motor function with development of pseudo-Parkinsonism(p. 88), sedation, depression, stuffy nose, impaired libido, and impotence increased appetite. These adverse effects have rendered the drug practically obsolete. 

Adverse effect Pseudo-parkinsonism, dystonia, and tardive dyskinesia... 

Reduce EPS dysfunction (pseudo-Parkinsonism, dystonias) caused by DA receptor antagonists. Diphenhydramine IM is especially useful in acute dystonias. 

DA receptor block is most intense with haloperidol, pimozide, and high-potency phenothiazines. Can result in reversible pseudo-Parkinsonism (bradykinesia, rigidity, tremor), akathisia, and... 

DA in the nigrostriatal tract helps regulate kinesis by inhibiting GABAergic and cholinergic neurons. The loss of DA neurons in this trad leads to excessive ACh activity and Parkinsonism. DA receptor antagonists cause a reversible pseudo-Parkinsonism agonists may cause dyskinesis. 

The typical antipsychotic drugs (e.g., chlorpromazine, thioridazine, fluphenazine, and haloperidol) act primarily as DA antagonists, blocking Dj receptors. Side effects include the induction of pseudo-Parkinsonism, akathisia, and/or acute dystonic effects. Their use and symptom management are discussed, as are other adverse effects including toxicity, tardive dyskinesia, and neuroleptic malignant syndrome. 

Clay PG, Adams MM Pseudo-Parkinson disease secondary to ritonavir-buspirone interacdcm. Ann Pharmacother (2003) 37,202-5. 

Neuroleptic malignant syndrome (2007) Kemp WL+, Am j Forensic Med Pathol 28(1), 59 (2006) Khan HM +. J Ayub Med Coll Abbottabad 18(1), 17 Parkinsonism (pseudo)... 

Extrapyramidal symptoms, akathisia, dystonia, tardive dyskinesia, drowsiness, headache, dry mouth, orthostatic hypotension Agitation, dizziness, nervousness, akathisia, constipation, fever, weight gain Hypotension, postural hypotension, tardive dyskinesia, photophobia, urticaria, nasal congestion, dry mouth, akathisia, dystonia, pseudo parkin son ism, behavioral changes, headache, photosensitivity Parkinson-like symptoms, motor restlessness, dystonia, oculogyric aisis, tardive dyskinesia, dry mouth, diarrhea, headache, rash, drowsiness... 

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