Therapeutic efficacy Hamsters

Therapeutic Efficacy of SDB Against Experimental HSV-1 Corneal Infection of Hamsters... 

Other benzimidazoles 46 (CDRI 82-437) has been found to display potent anti-filarial activity as it kills almost 100% of the microfilariae and adult worms of L. carinii, D. viteae and Brugia nialayi in rodents both by oral and parenteral route of administrations. The therapeutic dose of this compound is 10-50 mg/kg (i.p. or s.c.) or 100-200 mg/kg (oral) for 5 days. It also shows high activity against hookworms, A. ceylanicum in hamsters at an oral dose of 50 mg/kg [58,59]. Compound 52 (CDRI 81-470) exhibits 100% activity against different nematodes and cestodes in experimental and domestic animals at an oral dose of 2.5-100 mg/kg [67]. The efficacy of... 

Castanospermine has been screened for efficacy against simian immunodeficiency virus (265), and has been shown to prevent syncytium formation in feline astrocyte cultures infected with the feline immimodeficiency virus by modifying the viral cell envelope (266). It suppressed syncytium formation and hemolytic activity in baby hamster kidney cells infected with Newcastle disease virus however, synthesis and cell surface expression of the hemagglutinin-neuraminidase glycoprotein in the viral envelope were not affected, which strengthens the hypothesis that poor transport of the parent alkaloid across membrane barriers may limit its therapeutic use (267). Both 239 and its 6-0-butanoyl ester had comparable relative toxicities and antiviral effects on Rauscher murine leukemia virus (268), but the ester was more potent than the parent alkaloid in inhibiting replication of Moloney murine leukemia virus (258). The ester was also active against herpes simplex viruses types 1 and 2 (269,270). In the latter case, conclusive evidence was provided for intracellular hydrolysis to 239. 

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