HSV-1 corneal infection

Therapeutic Efficacy of SDB Against Experimental HSV-1 Corneal Infection of Hamsters... 

Herpes simplex keratitis (HSK) is caused by HSV type 1 in adults and is one of the most common infectious etiologies of blindness. It is second only to trauma as a cause of corneal blindness in the United States, where an estimated 50,000 new or recurrent cases are seen each year. Recurrent HSK can be reactivated by many factors in addition to those listed above. Reactivation has been reported in patients after penetrating keratoplasty, argon laser trabeculoplasty, Nd YAG laser peripheral iridotomy, or treatment with excimer lasers, including cases in which ocular herpes had not occurred previously. It is important to realize that because most patients have latent HSV it is possible for a reactivation to occur despite a negative history of a primary infection. 

Corneal involvement in the form of epithelial keratitis or dendrites occurs in up to 63% of initial clinical HSV infections.These tend to be small, late in onset, and transitory, lasting only 1 to 3 days. Stromal disciform keratitis, which manifests as a round area of stromal edema with an overlying intact epithelium, is much less frequent in... 

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