The Scripps Research Institute

This volume is based partly on the lecture notes of K. C. N. that were used for teaching courses at the University of Pennsylvania, the University of California, San Diego, and The Scripps Research Institute. We apologize sincerely to those whose brilliant works have been left out owing to the inevitable closing of the curtain and hope that in the event of a second volume we can rectify these omissions. We also apologize in advance for the inevitable errors that a volume of this size may contain, and welcome constructive comments from our readers in order to correct such errors in future editions. 

K. C. Nicolaou was bom in 1946 in Cyprus. He studied chemistry at the University of London (B.Sc., 1969 Ph.D., 1972), Columbia University (postdoctoral research) and Harvard University (postdoctoral research). Between 1976 and 1989 he was a faculty member at the University of Pennsylvania. He currently holds joint appointments at The Scripps Research Institute, where he is the Darlene Shiley Professor of Chemistry and Chairman of the Department of Chemistry, and at the University of California, San Diego, where he is Professor of Chemistry. His research interests span the areas of synthetic organic chemistry, bioorganic chemistiy, molecular design, and the chemistry and biology of natural products. 

Valery V. Fokin Department of Chemistry The Scripps Research Institute BCC-315... 

Joel M. Gotteseeld Department of Molecular Biology The Scripps Research Institute 10550 North Torrey Pines Road La Jolla, CA 92037 USA... 

The total synthesis of calicheamicin y/ by the research group of K. C. Nicolaou (The Scripps Research Institute, University of California, San Diego) represents a stunning achievement in synthetic organic chemistry. 

Dept, of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037... 

William A. Greenberg, Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Rd., La JoUa, CA 92307, USA... 

This is publication number 16768-NP from The Scripps Research Institute. The research was supported by National Institutes of Health Grants AA06420 and AA07456 from the National Institute on Alcohol Abuse and Alcohohsm. We are grateful for the assistance of Ehzabeth Gordon and Michael Arends in the preparation of this manuscript. 

Acknowledgements Financial support from the Natural Sciences and Engineering Research CouncU of Canada, the Canadian Institutes of Health Research (fellowship to M.A.J.) and the Skaggs Institute for Chemical Biology is gratefully acknowledged. This is manuscript 17973-MB from the Scripps Research Institute. 

The Scripps Research Institute 10550 North Torrey Pines Rd. 

The Genomics Institute of the Nopartis Research Foundation, San Diego, CA, 9212, Department of Cell Biology, The Scripps Research Institute, Ta folia, CA, 92037 and Howard Hughes Medical Institute, Department of Neurobiology and Physiology, Northwestern University, Evanston, IE 60208, USA... 

Molecular Graphics Laboratory, The Scripps Research Institute, San Diego, CA, US. http //autodock.scripps.edu. 

The Scripps Research Institute and University of California at San Diego, La Jolla, California... 

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