Tetracyclines Ethanol

Nonsteroidal anti-inflammatory drugs (naproxen and ibuprofen) Penicillins Phenylbutazone Probenecid Salicylates Sulfonamides Barbitu rates Phenytoin Probenecid Retinoids Salicylates Sulfonamides Sulfonylureas Tetracycline Ethanol Retinoids Dipyridamole... 

UV irradiation (335 nm) at pH 7.3 showed that some tetracyclines produced significant concentrations of the superoxide anion radical. Demeclocycline (122), oxytetracycline (123) and chlortetracycline (124) were the most active in this. These are all potent photosensitizers and probably give the observed exaggerated sunburn as a result of superoxide production in the skin [90]. Other photochemical experiments demonstrated the production of singlet oxygen. Yields obtained by luminescence measurements in alkaline ethanol were in the order (122) > (120) > (124) > (121) > (125). Chlortetracycline... 

Stock solutions of antibiotics 10 mg/mL kanamycin in water filter-sterilize 5 mg/mL tetracycline in ethanol store at -20°C. 

Soluble 1 in 10 of water and 1 in 100 of ethanol practically insoluble in chloroform and ether soluble in methanol and in aqueous solutions of alkali hydroxides and carbonates. Solutions in water become turbid on standing owing to hydrolysis and precipitation of tetracycline. 

Crystals from aq ethanol, mp 206°. Slightly sol in water, chloroform. Sol in acetone, methanol. DMF, aq solns above pH 8.0. Less sol in ethanol. Pharmaceut. Incompat Calcium gluconate, ascorbic acid, tetracyclines, urea, epinephrine. LDga orally in female, male rats 2600, 2820 mg/kg (Goldenthal). 

The thermodynamic proton-ligand (pJ a) metal-ligand stability constants of clioquinol, clofibrate, nitrofurazone, and tetracycline with Cu", Zn, Mn", Mg" and Ca" have been determined at 35 °C in 50% ethanol-water media. An empirical pH correction for... 

Steatosis, also known as fatty liver, results from the accumulation of excess lipid (more than 5% lipid by weight) in the liver. Many chemicals can cause this, and the lesions can be either acnte or chronic. Ethanol is a classic example, causing both acute and chronic lesions. It indnces large droplets of fat in the cell. On the other hand, snbstances snch as tetracycline and phosphorns produce many... 

The parent compound is tetracycline (international free name, yellow, light-sensitive cryst., mp. 170-175 °C, [a]u -239° (CHjOH), soluble in ethanol. 

Intriguingly, some of the properties of LMWGs, such as biodegradabihty, biocompatibility, and gende physical and chemical profiles, represent considerable potential in the fields of biomedicinal applications and drug delivery [58-62]. For this purpose, amphiphilic 3,4,5-trihydroxybenzoic derivatives with linkers of different lengths (26a, 26b, Fig. 3.23) were developed by us [63]. The compounds 26a and 26b with two naked -COOH are able to gel in aqueous ethanol, meanwhile, they can trap a great amount of tetracycline hydrochloride (TH) in gel tissue. In the presence of BSA or amino acids, TH could be controUably released into water solution. 

Tetracycline solution Dissolve 20 mg per mL of ethanol. Store in dark at -20 °C. Vortex before use. 

Absorption of digoxin in the stomach may be diminished. Absorption of oral medication (e.g. acetaminophen, levodopa, tetracycline, and ethanol) in the small bowel may be increased. Insulin dosage may require adjustment because the action of metoclopramide will influence the dehvery of food to the intestines and thus the rate of absorption. Metoclopramide increases the effect of succinylcholine and the serum levels of cyclosporine. 

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