Salicylates Probenecid

Drugs that may affect repaglinide include CYP 450 inhibitors (eg, clarithromycin, erythromycin, ketoconazole, miconazole), CYP 450 inducers (eg, barbiturates, carbamazepine, rifampin), beta blockers, calcium channel blockers, chloramphenicol, corticosteroids, coumarins, estrogens, gemfibrozil, isoniazid, itraconazole, levonorgestrel and ethinyl estradiol, MAOIs, nicotinic acid, NSAIDs, oral contraceptives, phenothiazines, phenytoin, probenecid, salicylates, simvastatin, sulfonamides, sympathomimetics, thiazides and other diuretics, and thyroid products. 

Drugs that may affect methotrexate include oral aminoglycosides, charcoal, chloramphenicol, folic acid, NSAIDs, PCNs, probenecid, salicylates, sulfonamides, TCN, trimethoprim. 

A number of drugs are known to inhibit the renal secretion of certain other drugs, resulting in decreased clearance of the latter. Examples of drugs decreasing the renal clearance of other drugs include probenecid, salicylates, sulfinpyrazone, phenylbutazone, and thiazide diuretics. As mentioned previously, the inhibition of penicillin secretion by probenecid due to competition between the two for renal tubule carriers is used therapeutically to increase penicillin blood levels. 

Clinically important, potentially hazardous interactions with aspirin, buprenorphine, methotrexate, probenecid, salicylates... 

Clinically important, potentially hazardous interactions with ACE inhibitors, amikacin, aminoglycosides, aminophylline, anti-diabetics, antihypertensives, cephalosporinss, cisplatin, gentamicin, indomethacin, kanamycin, neomycin, probenecid, salicylates, streptomycin, tobramycin... 

Nonsteroidal anti-inflammatory drugs (naproxen and ibuprofen) Penicillins Phenylbutazone Probenecid Salicylates Sulfonamides Barbitu rates Phenytoin Probenecid Retinoids Salicylates Sulfonamides Sulfonylureas Tetracycline Ethanol Retinoids Dipyridamole... 

Concomitant use with anticoagulants may increase plasma levels of both drugs and, after continued therapy, may reduce the plasma levels of anticoagulant effects. Use with chloramphenicol, guanethidine, insulin, monoamine oxidase inhibitors, probenecid, salicylates, or sulfonamides may enhance the hypoglycemic effect by displacing tolazamide from its protein-binding sites. 

Kim, M. Stewart, J.T. HPLC post-column ion-pair extraction of acidic drugs using a substituted a-phenylcinnamonitrile quaternary ammonium salt as a new fluorescent ion-pair reagent. J.Liq.Chromatogr., 1990, 13, 213-237 [derivatization fluorescence detection also benzoic acid, flu-fenamic acid, ibuprofen, ketoprofen, mefenamic acid, probenecid, salicylic acid, valproic acid]... 

Simultaneous ketoprofen, mefenamic acid, naproxen, probenecid, salicylic acid, valproic acid... 

Simultaneous aminopyrine, aspirin, caffeine, carbidopa, P-hydro fyethyltheophylline, p-hydroxypropyltheophylline, methicillin, methyldopa, n cillin, nifedipine, penicillamine, penicillin V, penicillin (, phthalic acid, probenecid, salicylic acid, theobromine, theophylline... 

Note. The simultaneous administration of drugs like probenecid, salicylate and other NSAIDs etc., directly interfere with its secretion and hence, should be avoided as far as possible. 

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