Testosterone benzoate

Androsten-3/ -ol-17-one acetate is reduced over Raney nickel to the 17jS-alcohol, which is protected as a benzoate. This allows the selective hydrolysis of the acetate with methanolic sodium hydroxide solution. A final Oppenau-er oxidation leads to testosterone benzoate, hydrolysis of which gives the target compound. 

Biogenetic-like olefinic cyclizations in nitroalkane solvents result in nucleophilic trapping of an intermediary polycyclic vinyl action by the nitroalkane to afford oxime ethersJ The ingenious application of this finding to secure an entry into 17-oxwenated steroids is portrayed in the facile synthesis of testosterone benzoate by Johnson et al. 

C 5H2j02 846-46-8) see Androstanolone Estrone (3p,17p) -androst-5-ene-3,17-diol 3-acetate (C21H32O3 1639-43-6) see Mesterolone Testosterone (3p,17p)-androst-5-ene-3,17-dioI 3-acetate 17-benzoate... 

MGA) (4) testosterone (5) propionate [57-85-2] in combination with estradiol benzoate, ie, Synovex-H or Heifer-oid and a synthetic testosterone analogue, trenbolone acetate [10161 -34-9] (TBA) (6) which is used alone, ie, Finaplix, or in combination with estradiol, ie, Revalor. Structures of these anabolic steroids are shown in Figure 1. 

The pure contribution from exciton coupling in testosterone 17/Mp-chlorobcnzoatc) (152) was estimated by subtracting the CD spectra of exciton interaction-free 17/J-hydroxy-4-en-3-one (153) and 4-en-3/3-ol-17/Mp-chlorobenzoate) (154) from the experimental CD spectrum of 152. The exciton CD curve (+16.2 (247), —12.8 (230)) obtained is much more symmetrical, as required by the theory349. Several more examples of benzoates and sorbates of steroidal 4-en-3-ones were treated in similar way, thus smoothing the imbalance of the exciton Cotton effects due to contributions of component chromophores. 

TESTOSTERONE PROPIONATE 20-MG -TESTOSTERONE PHENYLPROPIONATE 40-MG -TESTOSTERONE ISCAPRIOATE 40-MG -ESTRADIOL PHENYLPROPIONATE 4MG -ESTRADIOL BENZOATE 1-MG... 

IR Spectra of Benzyl Benzoate and Testosterone Cypionate Obtained from the LC/IR Interface... 

The steroids as a group tend to be poorly soluble in water. Their complex stmcture makes prediction of solubility somewhat difficult, but one can generally rationalise, post hoc, the solubility values of related steroids. Table 5.6 gives solubility data for 14 steroids. As examples, the substitution of an ethinyl group has conferred increased solubility on the estradiol molecule, as would be expected. Estradiol benzoate with its 3-OH substituent is much less soluble than the parent estradiol because of the loss of the hydroxyl and its substitution with a hydrophobic group. The same relationships are seen in testosterone and testosterone propionate. As both estradiol benzoate and testosterone propionate are oil soluble, they are used as solutions in castor oil and sesame oil for intramuscular and subcutaneous injection (see Chapter 9). 

The fight against aging should take into account not only the damage caused by the various sources of cell oxidation but also the fall in hormone levels. For menopausal or postmenopausal women, a standard formula is testosterone propionate 100 mg, estrone 5 mg, estradiol benzoate 5 mg, and water in oil excipient ad 100 g. 

Simultaneous benzyl alcohol, benzyl benzoate, boldenone, cedusterone, cortisone, dehy-droepiandrosterone (UV 210), ethisterone, fluoj mesterone, mesterolone (UV 210), meth-andriol (UV 210), methandrostenolone, methenolone acetate, methyltestosterone, mibol-erone, nandrolone, nandrolone acetate, nandrolone propionate, norethandrolone, norethindrone, norethindrone acetate, norgestrel, oxandrolone (UV 210), oxymetholone, stanozolol, testosterone, testosterone acetate, testosterone propionate, trenbolone acetate Interfering caffeine, formebolone, testolactone... 

Carignan, G. Lodge, B.A. Skakum, W. Simultaneous einalysis of estradiol dienanthate, estradiol 3-benzoate and testosterone enanthate benzilic acid hydrazone in oily formulations by gradient HPLC. J.Liq.Chromatogr., 1985, 8, 2567-2577 [formulations oils gradient simultaneous estradiol dienanthate, estradiol 3-benzoate, testosterone enanthate benzilic acid hydrazone 1,2,4,5-tetrachloro-... 

Me] was prepared by treatment of the pyrrolidine dienamine derivative of (163 R = H.R = Me) with l,3-dichlorobut-2-ene and potassium iodide in dry DMF. Reaction with lithium dimethylcopper gave the 9)S-methyl derivative (163b), whose 17/i-benzoate (163c) was treated with sulphuric acid to afford the corresponding diketone (163d). Finally, annelation of (163d) with ethanolic potassium hydroxide yielded the desired testosterone analogue (164). ... 

Bstradiol-17p benzoate + testosterone propionate 20 mg 200 mg Implant Heifers, calves Synovex H ImpUx EF... 

Srinivas and Srinivasulu (1993) found that heulandate layers developed with carbon disulfide-pyridine (1 1) were effective for the separation of steroid hormones,—dehydroepiandrosterone could easily be separated from mixtures of cholesterol and estradiol benzoate or testosterone phenylpropionate, and testosterone could be separated from mixtures of cholesterol and testosterone phenylpropionate or estradiol benzoate. Likewise, estradiol could easily be separated from mixtures of cholesterol and estradiol benzoate. Daeseleire et al. (1994) applied HPTLC and GC/MS for the detection of anabolic steroids used as growth promoters in illicit cattle fattening within the European market. Agrawal et al. (1995) developed a sensitive, reliable, and rapid silica gel TLC method for the separation, identification, and quantification of stereospecific androgen metabolites. 

Adams, N.R. (1983). Sexual-behavior of ewes with clover disease treated repeated with estradiol benzoate or testosterone propionate after ovariectomy. Journal of Reproduction cmdFertility, 68,113-117. Adams, N.R. (1990). Permanent infertility in ewes exposed to plant estrogens. Australian Veterinary... 

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