Testosterone administration

In men testosterone administration is indicated for primary hypogonadism, e.g. in Klinefelter syndrome or after orchidectomy, and for hypopituitarism. 

Sandblom RE, Matsumoto AM, Schoene RB, Lee KA, Giblin EC, Bremner WJ, Pierson DJ. Obstructive sleep apnea syndrome induced by testosterone administration. N Engl J Med 1983 308(9) 508-10. 

Jordan WP Jr. Allergy and topical irritation associated with transdermal testosterone administration a comparison of scrotal and nonscrotal transdermal systems. Am J Contact Dermat 1997 8(2) 108-13. 

EXCESS in childhood results in precocious puberty may result from a hormone-secreting tumor. In adults, testosterone administration has been used by athletes to increase body mass, but may be associated with side effects, including cardiac and liver disease, and testicular atrophy. 

Yu, Z. Gupta, S.K. Hwang, S.S. Cook, D.M. Duckett, M.J. Atkinson, L.E. Transdermal testosterone administration in hypogonadal men comparison of pharmacokinetics at different sites of application and at the first and fifth days of application. J. Clin. Pharmacol. 1997, 57, 1129-1138. Zobrist, R.H. Quan, D. Thomas, H.M. Stanworth, S. Sanders, S.W. Pharmacokinetics and metabolism of transdermal oxybutynin in vitro and in vivo performance of novel delivery system. Pharm. Res. 2003, 20, 103-109. Marzulli, E.N. Barriers to skin penetration. J. Invest. Dermatol. 1962, 39, 387-389. 

Testosterone is known to affect body fat distribution and insulin sensitivity in men. Testosterone administration has been shown to reduce total fat mass and improve insulin sensitivity. ]6°1... 

Kicman AT, Brooks RV, CoUyer SC, Cowan DA, Nanjee MN, Southan GJ, et al. Criteria to indicate testosterone administration. Br J Sports Med 1990 24 253-64. 

Miller K, Corcoran C, Armstrong C. Transdermal testosterone administration in women with acquired immunodeficiency syndrome wasting A pilot study. J Clin Endrocrinol Metab 1998 83 2717-2725. 

The close relationship between the thymus and the more classic endocrine organs is further illustrated by the results of studies designed to elucidate the effects of endocrine ablative surgery on thymus gland function. Prepubertal orchidectomy resulted in an increase in thymus weight and accelerated rejection of skin grafts (Castro, 1974). The effects are reversible by testosterone administration. Adrenalectomy also delayed the involution of the thymus (Dougherty, 1952 Ishidate and Metcalf, 1963). 

Ferrando AA, Sheffield-Moore M, Yeckel CW, et al. Testosterone administration to older men improves muscle function molecular and physiological mechanisms. Am J Physiol Endocrinol Metab 2002 282 E601-E607. 

Appleman E, Aggarwal S, Bhasin G, Hede-Brierley L, Bhatia A, Collins L, LeBrasseur N, Fiore LD, Bhasin S. Adverse events associated with testosterone administration. N Engl J Med 2010 363 109-22. 

Phillips, A. (1999) Gas chromatography combustion isotope ratio mass spectrometry for confirming testosterone administration from urinary androstanediols. Micromass Application Note 501. 

Shackleton, C.H.L., Phillips, A., Chang, T., Li, Y. (1997) Confirming testosterone administration by isotope ratio mass spectrometric analysis of urinary androstanediols. Steroids, 62,379-387. 

Even withont resistance exercise, testosterone administration can increase lean body mass,and a resistance exercise training program can magnify these effects. 

The observation of van der Horst and Brand that the concentration of hypotaurine in the follicle of the ewe is related to fertility suggests that the changes in hypotaurine after castration and testosterone administration may be related to fertility in the male. The high concentration of hypotaurine in the epidid3nnes could be related to maturation of the spermatozoa - ... 

Leatherland, J.F., and R.A. Sonstegard. 1980. Effect of dietary Mirex and PCBs in combination with food deprivation and testosterone administration on thyroid activity and bioaccumulation of organochlorines in rainbow trout Salmo gairdneri Richardson. Journal of Fish Diseases 3 115-124. 

Kicman, A.T., Brooks, R.V., CoUyer, S.C., et al (1990) Criteria to indicate testosterone administration. British Journal of Sports Medicine, 24, 253-264. 

---