Testes platinum

Kurnakov test - PLATINUM-GROUP METALS, COMPOUNDS] (Vol 19)... 

Tested platinum (Pt), palladium (Pd), and ruthenium (Ru) catalysts Initial rate measurements made for hexadecane and diesel fuel... 

Cominos et al. [324] tested platinum, mthenium and rhodium catalysts supported by alumina and ceria and bimetallic platinum catalysts, namely platinum/rhodium, platinum/cobalt and platinum/mthenium all supported by y-alumina. The samples were tested as coatings in microchannels. The feed was composed of 58 vol.% hydrogen, 21 vol.% carbon dioxide, 1.12 vol.% carbon monoxide, 4.6 vol.% oxygen and 15 vol.% nitrogen, which corresponded to an O/CO ratio of 8. Over mthenium/ platinum, rhodium/platinum and rhodium conversion close to 100% was achieved. 

Further test platinum compounds ability to inhibit cell division. 

Gold salts oxidize acetic acid solutions of benzidine to benzidine blue which is a quinoneimine type of dyestuff (compare page 283). Colored gold hydrosols are produced at the same time. Considerable quantities of heavy metals or alkali salts flocculate the reaction products and so prevent the formation of the sols and consequently impair the test. Platinum salts and oxidants which act on benzidine must be absent. 

In dynamic tests platinum and gold were resistant to attack under all conditions, but niobium corroded at an appreciable rate, about 7 mpy at 15 fps. The corrosion rate of niobium depended on the flow rate of the solution, and at higher flow rates somewhat higher corrosion rates were observed. Static tests showed that tantalum and chromium are corroded only slightly under most conditions. If the solution contained dissolved hydrogen, tantalum was seriously embrittled highly oxygenated uranyl-sulfate solutions at temperatures above 250 C oxidized chromium to the soluble hexavalent state, and under these conditions the rate of attack was several mils per year. 

This is an unusual drug in that it contains a metal atom, platinum (Pt) in this case. Cisplatin reacts with DNA to cross-link bases, disrupting normal DNA structure and function. This agent has found broad use in cancer chemotherapy, including efficacy in tumors of the testis, ovary, bladder, head and neck, thyroid, cervix, and endometrium. It is also active against neuroblastoma and osteogenic sarcoma. 

Fig. 7. Whole-body image (anterior to the left, posterior to the right) of a testis cancer patient 1 h after the end of a [191 Ptjcisplatin infusion. The platinum was still clearly detectable after 65 h but only weakly visible 7 days after the infusion. Chemotherapy was performed following surgery, so no macroscopic tumor tissue remained in the testis. In a different patient, however, platinum was detected in a metastatic tumor of the neck. Reprinted with permission from the Scandinavian University Press from [237].

Maines, M.D., P.M. Sluss, and M. Iscan (1990). cis-Platinum-mediated decrease in serum testosterone is associated with depression of luteinizing hormone receptors and cytochrome P-450scc in rat testis Endocrinology 126, 2398-2406. 

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