Tert Butyric acid

Butane, 1,4-diiodo-, 30, 33 2-Butanone, 3-acetamido-, 33,1 n-BuTYLACETYLENE, 30, IS tert-Butyl alcohol, 30, 19, 20 32, 20 ierl-Butylbenzene, 32, 91 n-Butyl bromide, 30, 16 tert-Butyl hypochlorite, 32, 20 n-Butyl iodide, 30, 34 Butylketene dimer, 31, 71 -ter -Butylphenyl salicylate, 32, 26 Butyrchloral, 33, IS Butyric acid, a, y-dicyano-o-phenyl-, ethyl ester, 30, 80... 

METHYL ISOBUTYL KETONE n-PENTYL FORMATE n-BUTYL ACETATE sec-BUTYL ACETATE tert-BUTYL ACETATE ETHYL n-BUTYRATE ETHYL ISOBUTYRATE ISOBUTYL ACETATE n-PROPYL PROPIONATE CYCLOHEXYL PEROXIDE DIACETONE ALCOHOL 2-ETHYL BUTYRIC ACID n-HEXANOIC ACID 2-ETHOXYETHYL ACETATE HYDROXYCAPROIC ACID PARALDEHYDE... 

Clofibrate Clofibrate, ethyl ether 2-(4-chloropheoxy)-M( -butyric acid (20.2.2), is synthesized by esterifying 2-(4-chlorophenoxy)-/yo-butyric acid (20.2.1) with ethyl alcohol. This is synthesized in a single-stage reaction from 4-chlorophenol, acetone, and chloroform in the presence of an alkali, evidently by initial formation of chlorethone-trichloro-tert-butyl alcohol, which under the reaction conditions is converted into (4-chlorophenoxy)trichloro-fert-butyl ether, and further hydrolyzed to the desired acid 20.2.1, which is further esterified with ethanol in the presence of inorganic acid [6-8]. 

In search of a convenient procedure for preparing diazo substrates for the cycloaddition to Cgg, Wudl introduced the base-induced decomposition of tosyl-hydrazones [116]. This procedure allows the in situ generation of the diazo compoimd without the requirement of its purification prior to addition to Cgg. Since they are rapidly trapped by the fullerene, even unstable diazo compounds can be successfully used in the 1,3-dipolar cycloaddition. In a one-pot reaction the tosyUiydrazone is converted into its anion with bases such as sodium methoxide or butylHfhium, which after decomposition readily adds to Cgg (at about 70 °C). This method was first proven to be successful with substrate 142. Some more reactions that indicate the versatility of this procedure are shown in Table 4.4. Reaction of 142 with CgQ under the previously described conditions and subsequent deprotection of the tert-butyl ester leads to [6,6]-phenyl-C5j-butyric acid (PCBA) that can easily be functionalized by esterification or amide-formation [116]. PCBA was used to obtain the already described binaphthyl-dimer (obtained from 149 by twofold addition) in a DCC-coupling reaction [122]. 

Tetrahydrobenzo[6]thiophen-4-one (103) may be prepared from y-(2-thienyl)butyric acid by cyclization with phosphoric acid854 or by Friedel-Crafts cyclization of the corresponding acid chloride.194, 355.358 j s 5-methyl,357 2-ethyl,194 2-isopropyl,358 2- and 3-tert-butyl,359 2,3-dimethyl,360 2-ethyl-3-methyl,360 and 2-bromo 354 derivatives and diethyl 4,5,6,7-tetrahydrobenzo[6]thiophene-4,5-di-carboxylate861 may be prepared similarly. 4,5,6,7-Tetrahydrobenzo-[6]thiophen-7-one (104)357 362,863 and its 5- and 6-methyl 357 and 2-chloro 362 derivatives are obtained from the appropriately substituted y-(3-thienyl)butyric acid, A recent patent 364 describes the vapor phase cyclization of y-(2-thienyl)butyric acid to 103. Ketones (103 and 104) are useful intermediates for the synthesis of 4- and 7-substituted benzo[6]thiophenes, respectively their reactions are discussed in Section VI, B, 4. 

In addition to the chain length, the effect of branching of the carbon chain was studied. Specificity of POS-PVA lipase was studied by monitoring esterification reactions of ft-butanol, sec-butanol, and ferf-butanol with butyric acid, as shown in Table 2. The highest rate of conversion to ester (60%) occurred in the presence of ft-butanol, compared with sec-butanol and ferf-butanol. The branching was found to decrease significantly the esterification yield by a factor of 0.4 for sec-butanol and 0.65 for tert-butanol. Antczak et al. (24) reported a similar conversion pattern. 

C11H14N2 2-tert-butyl benzimidazole 24425-13-6 397.15 34.097 1.2 22147 Cl1 HI402 4-(4-methytphenyl)butyric acid 4521-22-6 480.16 41.981 2... 

Water with ethanol, w-propanol and isopropanol, tert-butanol, propionic acid, butyric acid, pyridine, methanol with methyl iodide, methyl acetate, chloroform,... 

From 1-tert-butyl 2-ethyl S-acetyl-6-oxopiperidine-l,2-dicarboxy-late. Treatment of Boc-protected 5-acetyl-6-oxopiperidine-2-carboxylic acid ethyl ester 218 with a 64% aqueous solution of hydrazine in acetonitrile gave (R,S)-2-ferf-butoxycarbonylamino-4-(3-oxopyrazol-4-yl)butyric acid 219, in 67% yield. The corresponding 1-methyl derivative 220 was obtained in only 17% yield by treating 218 with methylhydrazine under similar conditions (99EJMC967) (Scheme 49). 

AI3-11509 Butanoic acid, 3,3-dimethyl-2-oxo- tert-But-ylglyoxylic acid Butyric acid, 3,3-dimethyl-2-oxo- 3,3-Dimethyl-2-oxobutyric acid 3,3-Dimethyl-2-oxobutan-oic acid EINECS 212-418-2 Glyoxylic acid, tert-butyl- HSDB 5757 NSC 16648 Pyruvic acid, trimethyl- Trimethylpyruvic acid. Crystals mp = 90,5° bp = 189, bpi5 = 80° 4m= 312 nm (e = 30, etOH) slightly soluble in H2O, soluble in Et20, CeHe, CHCI3, CS2. 

The most extensive investigation on the deamination of trans- and cis-4- tert-butyl)cyclohexylamine (7.89 and 7.90, respectively) by the three procedures mentioned was conducted by Whiting s group (Maskill et al., 1965 Maskill and Whiting, 1976) in acetic acid (in part in butyric acid). 

There is also a later report by the same group regarding the use of a related catalyst 127 in the Michael addition of a-nitro ketones to enones (Scheme 6.19). In this case, a variety of peptides were tested as eatalysts but the best results were obtained with pentapeptide 127, in whieh, among many other different changes, the a-amino iso-butyric acid was employed instead of tert-leucine for the p-turn inducer sequence an additional modified arginine and a phenylalanine methyl ester were incorporated at the NH2 and the CO2H ends respectively. This catalyst furnished the final Michael adducts with moderate enantioselectivities, albeit in good yields in many cases. 

Carbonium ions are formed by splitting off hydrogen halide from the allyl halides. Since primary and secondary allyl halogenides are less reactive, only tertiary alkyl halogenides may be converted in high yield. Thus, sec. butyl chloride yields only 30 % of 2-methyl butyric acid whereas tert. butyl chloride forms pivalic acid in 76 % yield. 

Thio[diethyl-3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate] 3,9-Bisl,l-dimethyl-2-[3-(3-tert-butyl-4-hydroxy-5-methylphenyl)-propionyloxy]ethyl-2,4,8,10-tetraoxaspiro[5,5]undecane l,l/3-Tris(2-methyl-4-hydroxy-5-tert-butylphenyl)butane l,3/5-Trimethyl-2,4,6-tris(3,5-di-tert-butyl-4-hydroxybenzyl)benzene Bis[3,3 -bis(4 -hydroxy-3 -tert-butylphenyl)butyric acid] glycol ester 2-(3, 5 -di-fert-butyl-4-hydroxyphenyl)-methyl-4-(2,4-di-tert-butyl-3-hydroxyphenyl)methyl-6-tert-butylphenol... 

CsHi602 butyric acid tert-butyl ester 2308-38-5... 

Complementary to the work with aqueous acidic media is the study of the homolytic decompositions of Co(III) carboxylates in carboxylic acid media by Lande and Kochi . For example, Co(III) is reduced in pivalic acid media with first-order kinetics with E = 30.6 kcal.mole , AS = 8 eu and k ko = 1.28+0.10 (69 °C). The main oxidation products were found to be isobutylene and tert-butyl pivalate, which suggests that (CH3)3C- is an intermediate. Oxidative decarboxylation is the probable course in the analogous oxidations of n-butyric and isobutyric acids, in view of the production of propane and CO2 under normal... 

Both tert-butyl hypochlorite and N-chlorosuccinimide dehydrogenate primary benzylic alcohols to the aldehydes (equation 213), whereas primary aliphatic alcohols are converted into esters of the corresponding acids [709]. Butyl alcohol dissolved in carbon tetrachloride and treated with tert-butyl hypochlorite in the presence of pyridine at 40-45 C gives, after 2 h, a 66% yield of butyl butyrate [709]. 

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