Clofibral - Clofibrate

Just as important was the fact that CFA, when administered orally as the ethyl ester clofibrate (Clofibrate), could be given in high doses (2 g day ). X-ray analyses of cocrystallized Hb and CFA showed two binding sites, one strong and one very weak, separated by several angstroms [27]. 

Clofibrate Clofibrate, ethyl ether 2-(4-chloropheoxy)-M( -butyric acid (20.2.2), is synthesized by esterifying 2-(4-chlorophenoxy)-/yo-butyric acid (20.2.1) with ethyl alcohol. This is synthesized in a single-stage reaction from 4-chlorophenol, acetone, and chloroform in the presence of an alkali, evidently by initial formation of chlorethone-trichloro-tert-butyl alcohol, which under the reaction conditions is converted into (4-chlorophenoxy)trichloro-fert-butyl ether, and further hydrolyzed to the desired acid 20.2.1, which is further esterified with ethanol in the presence of inorganic acid [6-8]. 

Bile acid Bile acid Clofibrate Clofibrate... 

Fibric Acid Derivatives. Fibtic acid derivatives have been used since the 1960s for control of blood Upid levels. The four most well-known compounds in this class ate fenofibrate, gemfibrozil, clofibrate, and bezafibrate, shown in Table 5. Fenofibrate has been the most popular fibtic acid derivative in Europe, and has mote tecentiy been investigated extensively in clinical trials in the United States (153). Bezafibrate is stmcturaHy related to clofibrate, and has tecentiy been reviewed by Western European and AustraUan clinical trials (154). 

Clofibrate, shown to be an effective Upid lowering dmg in the eady 1960s, is the ethyl ester of/ -chlotophenoxy isobutyric acid. Gemfibrozil is a stmctural congener of clofibrate. 

Disubstituted aryloxyacetic acid derivatives related to clofibrate have been intensively studied in an attempt to get around the side effects of the latter drug. 

Ciprofibrate (48), a more potent lipid-lowering agent clofibrate, is prepared from Simmons-Smith product by Sandmeyer replacement of the amino group by a hydroxyl via the diazonium salt. Phenol undergoes the Reimer-Thiemann like process common to these agents upon alkaline treatment with acetone and chloroform to complete the synthesis of ci profib-rate (48). 

Bephenium hydroxy nephthoate a-(p-Chlorophenoxy)isobutyric acid Clofibrate... 

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