Teratogenic drugs

Beckman, D. A. and Brent, R.L. (1986). Mechanism of known environmental teratogens drugs and chemicals. Clin. Perinatal. 13 649-687. 

Similarly, fentanyl is a teratogenic drug contraindicated for use during pregnancy. The fentanyl patch does not induce anesthesia (loss of consciousness) but does produce analgesia. 

The teratogenic drugs can affect different stages of pregnancy i.e. 

A book of interest is "Chemically Induced Birth Defects," by Schardein (ref. 6). This reference book contains data on human and animal studies on birth defects and teratogens. Drugs are covered extensively. Chemicals discussed are pesticides, metals, industrial solvents, diagnostic agents, dyes, radioactive chemicals, plastics, toxins, food additives, air-water-soil pollutants, personal chemicals, etc. 

Neuropeptides are a new class of potential teratogenic drugs about to be marketed and suggested to have teratogenic effects (ref. 48). 

Amore BM, Kalhom TF, Skiles GL, et al. Characterization of carbamazepine metabolism in a mouse model of carbamazepine teratogenicity. Drug Metab Dispos 1997 25 953-962. 

Pregnancy (A). Limb malformations induced by the hypnotic thalidomide (Contergan) first focused attention on the potential of drugs to cause malformations (teratogenicity). Drug effects on the unborn fall into two basic categories ... 

The crucial point is that armed with this cautionary information, physicians do not prescribe any potentially teratogenic drugs where the risk of birth defects would outweigh any benefits. 

Pregnancy can affect seizure disorder which worsens in about a third, improves in a third, and remains unchanged in the remainder. Ideally, patients should have their seizure disorder properly investigated and treated before pregnancy with the best control achieved on the lowest dose of the least teratogenic drug. Major seizures are harmful to the developing fetus because of the possibility of anoxia and metabolic disorder. Minor seizures are probably harmless and therefore need not be eradicated. Patients... 

Hansen s Disease (leprosy) and without peripheral neuritis. What has been the response, in terms of risk management programs, to allow patients to have access to this teratogenic drug ... 

Ungvary G. 1985. The possible contribution of industrial chemicals (organic solvents) to the incidence of congenital defects caused by teratogenic drugs and consumer goods An experimental study. In Marois M, ed. Prevention of physical and mental congenital defects. PartB ... 

Tuchmann-Duplessis, H. Teratogenic drug screening. Present procedures and requirements. Teratology, 1972, 271-286. 

Journal of the American medical Association (1975) There s no safe trimester with teratogenic drugs (Editorial). 234, 264. 

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