Tedania ignis

Hyella caespitosa Bron et Flah Tedania ignis Nostoc sphaericum Tolypothrix tjipanasensis New Zealand Ascidian Australian Ascidian Didemnum sp. 

In 1991, Dillman and Cardellina reported the isolation of 1-methylcarbazole (384) from extracts of the sponge Tedania ignis collected in the shallow waters of Bermuda (350). This was the first report on the isolation of 1-methylcarbazole from a marine invertebrate (350). Prior to this isolation, 1-methylcarbazole was detected, along with other methylcarbazole derivatives as major components of cigarette smoke condensate (351). This isolate showed insecticidal and antimicrobial activity (352), but was shown to be non-mutagenic (353). 

The diketopiperazine cycZo-(L-proline-L-thioproline) (498) was isolated from Tedania ignis but a bacterial origin for the metabolite was suggested [423]. Cyc/o-(L-proline-L-methionine) (499) was isolated from Pseudomonas aeruginosa associated with the Antarctic sponge, Isodictya setifera. The structure was elucidated by spectroscopic methods and confirmed through synthesis [424],... 

The thiol group can also be found in heterocyclic compounds such as 2-mercaptobenzothiazole (9) and echinoclathrine C (10). Compound 9 was isolated from the symbiont bacterium Micrococcus sp., which was obtained from the sponge Tedania ignis [13]. The pyridine alkaloid echinoclathrine C (10) and its S-acetylated derivative, echinoclathrine B (11), were isolated from the Okinawan sponge Echinoclathria sp. [14]. The position of the hydroxyl and acylamino group on the phenyl ring in echinoclathrines (11 and 10) was recently corrected [15]. Compound 11 showed weak immunosuppressive activity in the mixed lymphocyte reaction assay with an IC50 of 9.7 pg/ml [14]. 

Tedania ignis Larva Lecithotrophic Coral, fish 68, 72... 

Tebbe olefination, 441 Tebbe olefinations, 368 Tebbe s reagent, 457 Tedania ignis, 246 Tedanolide, 246 tedanolide, 256 TEMPO, 250, 301 temporary silicon tether, 103 Tennant quinoline synthesis, 7 tetra-n-butylammonium fluoride (TBAF), 214 2-(7-aza-1 H-benzotriazole-1 -yl)-1,1,3, 3-tetramethyluronium hexafluorophosphate (HATU), 25... 

Fisher (1978) reports dermatitis caused by Tedania ignis. Fibula nolitangere and Macrociona prolifera. T. ignis (the fire sponge ) is abundant in the Miami... 

Prod, by Streptomyces gancidicus, Nocardia restricta, Candida albicans, Guignardia laricina and several Ceratocystis spp. Also isol. from the sponge Tedania ignis. Bitter component of sake and contributes to the flavour of beer. Shows antitumour and antifungal props. Phytotoxin associated with fungal diseases of trees. Cryst. Mp 168-172° (158-159°). [ot] -133° (c, 1 in EtOH), [a]2J -> 144° (c, 0.5 in H2O). 

Isol. from cocoa metab. product of the Caribbean sponge Tedania ignis. Mp 153-156°. [a] g —160.0° (c, 1 in EtOH). 

Three diketopiperazines cyclo-(L-Pro-L-Leu) (283), cyclo-(L-Pro-L-Val) (284), and cyclo-(Pro-Ala) (285) have been identified from an extract of Tedania ignis (99). 

Sevcik, C., and C.A. Barboza The Presynaptic Effect of Fractions Isolated from the Sponge Tedania ignis. Toxicon 21, 191 (1983). 

Mebs, D. Lack of Toxins in Alcoholic Extracts of the Sponge Tedania ignis. Toxicon 22, 821 (1984). 

Synthesis of Tedanalactam Tedanalactam 80 is a cfr-3,4-epoxy-2-piperidone with promising antifungal activity that was first isolated from sponge Tedania ignis in... 

Lastly, tedanol isolated from a Caribbean Tedania ignis collected in the mangroves of Sweeting Cay, Grand Bahama Island, is a brominated and sulfated diterpene with ent-pimarane skeleton. This original diterpene displays potent anti-inflammatory activity by inhibition of COX-2 (cyclooxygenase 2) expression thus, tedanol appears as a non-steroidal anti-inflammatory (Costantino et al, 2009b). 

Costantino, V, Fattorusso, E., Mangoni, A., Perinu, C., Cirino, G., De Gruttola, L., and Roviezzo, F. (2009b) Tedanol A potent antiinflammatory ent-pimarane diterpene from the Caribbean sponge Tedania ignis. Bioorg. Med. Chem., 17, 7542-7547. 

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