Technetium recent developments

Hnatowich, D. J. (1990) Recent developments in the radiolabeling of antibodies with iodine, indium, and technetium. Sem. Nuclear. Med. 20, 80-91. 

Introduction.—The identification of technetium in stars has been confirmed, thus establishing that stellar synthesis of this element is occurring. Recent developments in the analytical chemistries of technetium and rhenium have been reviewed, as has the extraction of rhenium from hydrochloric acid solutions a text describing the analytical chemistry of technetium and other man-made elements has been published. ... 

Technetium(I) chemistry initiated by (Alberto et al. 2001) is greatly facilitated by the available Tc(I)-tricarbonyl synthon. Recent developments and investigations are presented in Sect. 2.2. 

HTia receptor and the alphal-adrenergic receptor. Nucl Med Biol 29 375-387 Hnatowich DJ, Nakamura K (2004) Antisense targeting in cell culture with radiolabelled DNAs - a brief review of recent progress. Ann of Nucl Med 18 363-368 Horn RK, Katzenellenbogen JA (1997) Technetium-99m-labelled receptor-specific small-molecule radiopharmaceuticals recent developments and encouraging results. Nucl Med Biol 24 485-498 Iwasaki T, Iwasaki I, Aihara Y et al (2001) Immunoscintigraphy of aortic dissection with " Tc-la-belled murine anti-smooth muscle myosin monoclonal antibody in rats. J Nucl Med 42 130-137... 

Boyd RE (1973) Recent developments in generators of " Tc (IAEA-SM-171/94) In Radiopharmaceuticals labelled compounds 1973. IAEA Vienna, pp 3-26 Boyd RE (1982) Technetium-99m generators - the available options. Int J Appl Radiat Isot 33 801-810... 

The use and importance of technetium-99 m in nuclear medicine has been noted many times (1-4), and is further discussed by Marzilli et al. in this symposium (5). However, realization of the full potential of tech-netium-99m for diagnostic imagir of internal organs will require a much more extensive and detailed knowledge of technetium chemistry than is now available (1-5). This review covers some recent developments in the synthetic and structural aspects of technetium chemistry that may be relevant to the preparation, use, and understanding of the mode of action, of technetium radiopharmaeeuticals. 

Horn RK and Katzenellenbogen JA (1997) Technetium-99m-labeled receptor-specific small-molecule radiopharmaceuticals recent developments and encouraging results. Nuclear Medicine and Biology 24 485-498. 

The reduction of pertechnetate with concentrated hydrochloric acid finally yields the tetravalent state, and no further reduction to the tervalent state takes place. Therefore, the tervalent technetium complex has usually been synthesized by the reduction of pertechnetate with an appropriate reductant in the presence of the desired ligand. Recently, the synthesis of tervalent technetium complexes with a new starting complex, hexakis(thiourea)technetium(III) chloride or chloropentakis(thiourea)technetium(III) chloride, has been developed. Thus, tris(P-diketonato)technetium(III) complexes (P-diketone acetylacetone, benzoyl-acetone, and 2-thenoyltrifluoroacetone) were synthesized by the ligand substitution reaction on refluxing [TcCl(tu)5]Cl2 with the desired P-diketone in methanol [28]. 

More recently, a new chelation method based on the technetium chelator, HYNIC, was developed by Laverman et al. (36). HYNIC is well known for its use in labeling peptides and proteins with high efficiency and excellent stability (37). A-hydroxysuccinimidyl hydrazino nicotinate hydrochloride was conjugated to the free amino group of distearoylpho-sphatidyl-ethanolamine (DSPE) and subsequently incorporated in the lipid bilayer during the liposome preparation. 

The field of nuclear medicine has grown tremendously in the last two decades largely as a result of the development of the Mo-99/Tc-99m generator system. The ready availability of Tc-99m created a mushrooming interest in nuclear medicine clinical and research activity. Technetium-99m in a variety of forms is annually used in millions of nuclear medicine procedures performed worldwide. During recent years there has been a significant increase in interest in very short-lived (<30 min)... 

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