Technetium chelate

Technetium-chelates with heterocyclic ligands 98CSR43. 

Technetium chelates as potential small molecule radiopharmaceuticals 99CRV2205. 

More recently, a new chelation method based on the technetium chelator, HYNIC, was developed by Laverman et al. (36). HYNIC is well known for its use in labeling peptides and proteins with high efficiency and excellent stability (37). A-hydroxysuccinimidyl hydrazino nicotinate hydrochloride was conjugated to the free amino group of distearoylpho-sphatidyl-ethanolamine (DSPE) and subsequently incorporated in the lipid bilayer during the liposome preparation. 

DPPB)(tricine)] interconvert at elevated temperatures, suggesting that the presence of these isomers might be due to conformational changes in the macro-cyclic technetium chelate. The LC-MS data for these two macrocyclic 99mTc complexes are completely consistent with the proposed composition. These phosphine-containing HYNIC chelators may have the potential to act as bifunctional chelators for 99mTc labeling of small BMs [56]. 

Pietzsch HJ, Seifert S, Syhre R et al (2003) Synthesis, characterization, and biological evaluation of technetium(III) complexes with tridentate/bidentate S,E,S/P,S coordination (E=0, N(CH3), S) a novel approach to robust technetium chelates suitable for linking the metal to biomolecules. Bioconjug Chem 14 136-143... 

As a new approach toward the inhibition of ribonucleases, the water-stable ribonu-cleoside technetium-chelate... 

The structure of a rhenium(V) complex with l,3,5-trideoxy-l,3,5-tris (2-hydroxybenzylamino)-c /i -inositol has been described, and the metal ion sequestering abilities of borate esters of 2-amino-2-deoxy-D-gluconate and 2-amino-2-deoxy-D-galactonate have been studied. The largest effects were measured upon adding Cd(ll) or Ni(II) to the borate - 2-amino-2-deoxy-D-gluconate system. A ribonucleoside technetium chelate prepared from 2, 3 -diamino-2, 3 -dideoxyadenosine is mentioned in Chapter 20. 

FIGURE 18. (a) A tripodal technetium chelator is based on three oxime ligands tethered through an acyclic boronate triester, (b) Borosilicate macrocycles and (c) cages have been formed as building blocks and (d) assembled via coordinative ditopic Lewis bases. 

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