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Tc -HEDP

Tc-pyrophosphate, Tc-glucoheptonate, Tc-tetracycline and Tc-HEDP (hydroxy-ethylidene) diphosphonate... [Pg.93]

Figure 2. Comparative biodistributions of Tc-HEDP, " Tc(Sn)-HEDP, and "Tc(NaBH,)-HEDP in Sprague Dawley rats at 3 h post iv dose. Each point represents the average of 5 determinations. Figure 2. Comparative biodistributions of Tc-HEDP, " Tc(Sn)-HEDP, and "Tc(NaBH,)-HEDP in Sprague Dawley rats at 3 h post iv dose. Each point represents the average of 5 determinations.
The proportion of a Tc bone agent which is taken up by bone after intravenous injection will be affected by its binding to proteins in the blood serum. The proportions of the plasma Tc which were protein bound two hours after administration were found to be 16, 31, 54 and 85% with HEDP, MDP, PYP and tripolyphosphate respectively. In addition, the proportion of the administered dose of Tc which was taken up in bone was found to increase linearly with the fraction of Tc in the plasma which was not protein bound. Cox has reported a linear decrease in bone uptake with molecular weight for this series of bone agents, an observation which appears to reflect differences in their plasma protein binding behaviour. Thus the blood serum proteins may compete with bone for the Tc complexes and reduce the bone labelling efficiency of the radiopharmaceutical. The "Tc-diphosphonate formulations showed better performance in this respect than "Tc-PYP or Tc-tripolyphosphate. [Pg.987]

Diphosphonates labelled with " Tc have long been used as radiopharmaceuticals for bone imaging. When labelled with beta emitting isotopes, these agents have the potential for use as therapeutic agents for the treatment of bone metastases. Rhenium-188 labelled HEDP has attractive features as a... [Pg.104]

The criteria for inclusion of animals in the study were a biopsy proven osteosarcoma and a positive Tc-methylene diphosphonate scan for tumour localization. Fourteen dogs were used for the study. Animals that met the inclusion criteria received a single injection of Rc-HEDP with an activity ranging from 1.1 to 2.3 GBq, depending on the body size of the animal. [Pg.106]

Various diphosphonates such as MDP, HOP and HEDP labelled with Tc have been investigated for use as bone seeking radiopharmaceuticals. The chemistry of rhenium is similar to that of technetium, and comparative... [Pg.110]

De Groot GJ, Das HA, deLigny CL (1986b) Separation of Tc-99m(Sn)HEDP complexes by HPLC and GPC. Int J Appl Radiat Isot 37 23-27... [Pg.142]

McRae J, Hambright P, VaUc P, Bearden AJ (1976) Chemistry of Tc-99m tracers. II. In vitro conversion of tagged HEDP and pyrophosphate (bone seekers) into gluconate (renal agent). Effects of Ca and Fe(II) on in vivo distribution. J Nucl Med 17 208-211 Pauwels EKJ, Blom J, Camps JAJ, Hermans J, Rijke AM (1983) A comparison between the efficacy of " Tc-MDP, c-DPD, c-HDP for the detection of bone metastases. Eur J Nucl Med 8 118-122... [Pg.289]

Figure 1. HPLC separation of aqueous Tc(NaBH,J-HEDP mixture... Figure 1. HPLC separation of aqueous Tc(NaBH,J-HEDP mixture...

See other pages where Tc -HEDP is mentioned: [Pg.252]    [Pg.380]    [Pg.397]    [Pg.399]    [Pg.95]    [Pg.104]    [Pg.106]    [Pg.252]    [Pg.380]    [Pg.397]    [Pg.399]    [Pg.95]    [Pg.104]    [Pg.106]    [Pg.282]    [Pg.125]    [Pg.118]    [Pg.251]    [Pg.252]    [Pg.974]    [Pg.984]    [Pg.984]    [Pg.987]    [Pg.987]    [Pg.987]    [Pg.4765]    [Pg.974]    [Pg.984]    [Pg.984]    [Pg.985]    [Pg.987]    [Pg.987]    [Pg.103]    [Pg.17]    [Pg.398]    [Pg.282]    [Pg.4764]    [Pg.7119]    [Pg.7129]    [Pg.7129]    [Pg.7130]    [Pg.7132]    [Pg.7132]    [Pg.7132]    [Pg.104]    [Pg.117]   
See also in sourсe #XX -- [ Pg.104 ]




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HPLC separation of aqueous Tc(NaBH,)-HEDP

Tc(Sn)-HEDP

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