HPLC separation of aqueous Tc NaBH, -HEDP

ACS Symposium Series American Chemical Society Washington, DC, 1980. 

In summary, substitution routes have the potential of introducing hitherto unattainable flexibility and subtlety into the preparation of technetium radiopharmaceuticals. As currently being developed, these routes should lead to new classes of technetium radiopharmaceuticals, the properties of which will be considerably different and more easily controlled than those of complexes prepared by the standard Sn(n) reduction of pertechnetate. 

Because of the nascent state of technetium chemistry, considerable emphasis is currently being given to the characterization of technetium complexes by single crystal x-ray structure analysis. These analyses provide a firm foundation upon which subsequent development and elaboration of technetium chemistry may be based. Approximately twenty technetium complexes have been characterized by single crystal x-ray methods (p, and several of the resulting structures have considerable relevance to radiopharmaceutical development. 

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